Carcinoid tumor arising in a duplication cyst of the duodenum

Hiroaki Hata, Nobuyoshi Hiraoka, Hidenori Ojima, Kazuaki Shimada, Tomoo Kosuge, Tadakazu Shimoda

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Reported herein is a case of carcinoid tumor arising in a duplication cyst of the duodenum in a 34-year-old woman. Ultrasonography at a health check-up revealed a 10 cm cystic mass located in the retroperitoneum adjacent to the third portion of the duodenum. Macroscopically, it had a smooth surface without communication with other organs and was filled with brownish necrotic fluid. More than half of the inner wall was occupied by a white, irregular, and solid nodule, which protruded into the lumen. The nodule was diagnosed as a carcinoid tumor invasive to the deep muscular layer. The non-neoplastic cyst wall had bowel structures including mucosa, submucosa and double layers of smooth muscle, indicating that the lesion was a duodenal duplication cyst. Most of the mucosa was eroded by marked inflammation. The remaining mucosa consisted of various types of epithelium, the major type having the nature of primitive gastric mucosa. Of interest was the presence of hamartomatous components in the wall. Furthermore, the non-neoplastic mucosal lining cells around the carcinoid tumor expressed neuroendocrine antigens and had minimal proliferative activity, suggesting that part of the cyst wall provided a microenvironment for accelerated differentiation of epithelial cells to an endocrine phenotype and transformation to neoplasia.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalPathology International
Volume56
Issue number5
DOIs
Publication statusPublished - 2006 May
Externally publishedYes

Fingerprint

Carcinoid Tumor
Duodenum
Cysts
Mucous Membrane
Gastric Mucosa
Smooth Muscle
Ultrasonography
Epithelium
Epithelial Cells
Communication
Inflammation
Phenotype
Antigens
Health
Neoplasms

Keywords

  • Carcinoid tumor
  • Duodenum
  • Duplication cyst

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Carcinoid tumor arising in a duplication cyst of the duodenum. / Hata, Hiroaki; Hiraoka, Nobuyoshi; Ojima, Hidenori; Shimada, Kazuaki; Kosuge, Tomoo; Shimoda, Tadakazu.

In: Pathology International, Vol. 56, No. 5, 05.2006, p. 272-278.

Research output: Contribution to journalArticle

Hata, H, Hiraoka, N, Ojima, H, Shimada, K, Kosuge, T & Shimoda, T 2006, 'Carcinoid tumor arising in a duplication cyst of the duodenum', Pathology International, vol. 56, no. 5, pp. 272-278. https://doi.org/10.1111/j.1440-1827.2006.01957.x
Hata, Hiroaki ; Hiraoka, Nobuyoshi ; Ojima, Hidenori ; Shimada, Kazuaki ; Kosuge, Tomoo ; Shimoda, Tadakazu. / Carcinoid tumor arising in a duplication cyst of the duodenum. In: Pathology International. 2006 ; Vol. 56, No. 5. pp. 272-278.
@article{f77fea46d2304754affad94c41cdbc05,
title = "Carcinoid tumor arising in a duplication cyst of the duodenum",
abstract = "Reported herein is a case of carcinoid tumor arising in a duplication cyst of the duodenum in a 34-year-old woman. Ultrasonography at a health check-up revealed a 10 cm cystic mass located in the retroperitoneum adjacent to the third portion of the duodenum. Macroscopically, it had a smooth surface without communication with other organs and was filled with brownish necrotic fluid. More than half of the inner wall was occupied by a white, irregular, and solid nodule, which protruded into the lumen. The nodule was diagnosed as a carcinoid tumor invasive to the deep muscular layer. The non-neoplastic cyst wall had bowel structures including mucosa, submucosa and double layers of smooth muscle, indicating that the lesion was a duodenal duplication cyst. Most of the mucosa was eroded by marked inflammation. The remaining mucosa consisted of various types of epithelium, the major type having the nature of primitive gastric mucosa. Of interest was the presence of hamartomatous components in the wall. Furthermore, the non-neoplastic mucosal lining cells around the carcinoid tumor expressed neuroendocrine antigens and had minimal proliferative activity, suggesting that part of the cyst wall provided a microenvironment for accelerated differentiation of epithelial cells to an endocrine phenotype and transformation to neoplasia.",
keywords = "Carcinoid tumor, Duodenum, Duplication cyst",
author = "Hiroaki Hata and Nobuyoshi Hiraoka and Hidenori Ojima and Kazuaki Shimada and Tomoo Kosuge and Tadakazu Shimoda",
year = "2006",
month = "5",
doi = "10.1111/j.1440-1827.2006.01957.x",
language = "English",
volume = "56",
pages = "272--278",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Carcinoid tumor arising in a duplication cyst of the duodenum

AU - Hata, Hiroaki

AU - Hiraoka, Nobuyoshi

AU - Ojima, Hidenori

AU - Shimada, Kazuaki

AU - Kosuge, Tomoo

AU - Shimoda, Tadakazu

PY - 2006/5

Y1 - 2006/5

N2 - Reported herein is a case of carcinoid tumor arising in a duplication cyst of the duodenum in a 34-year-old woman. Ultrasonography at a health check-up revealed a 10 cm cystic mass located in the retroperitoneum adjacent to the third portion of the duodenum. Macroscopically, it had a smooth surface without communication with other organs and was filled with brownish necrotic fluid. More than half of the inner wall was occupied by a white, irregular, and solid nodule, which protruded into the lumen. The nodule was diagnosed as a carcinoid tumor invasive to the deep muscular layer. The non-neoplastic cyst wall had bowel structures including mucosa, submucosa and double layers of smooth muscle, indicating that the lesion was a duodenal duplication cyst. Most of the mucosa was eroded by marked inflammation. The remaining mucosa consisted of various types of epithelium, the major type having the nature of primitive gastric mucosa. Of interest was the presence of hamartomatous components in the wall. Furthermore, the non-neoplastic mucosal lining cells around the carcinoid tumor expressed neuroendocrine antigens and had minimal proliferative activity, suggesting that part of the cyst wall provided a microenvironment for accelerated differentiation of epithelial cells to an endocrine phenotype and transformation to neoplasia.

AB - Reported herein is a case of carcinoid tumor arising in a duplication cyst of the duodenum in a 34-year-old woman. Ultrasonography at a health check-up revealed a 10 cm cystic mass located in the retroperitoneum adjacent to the third portion of the duodenum. Macroscopically, it had a smooth surface without communication with other organs and was filled with brownish necrotic fluid. More than half of the inner wall was occupied by a white, irregular, and solid nodule, which protruded into the lumen. The nodule was diagnosed as a carcinoid tumor invasive to the deep muscular layer. The non-neoplastic cyst wall had bowel structures including mucosa, submucosa and double layers of smooth muscle, indicating that the lesion was a duodenal duplication cyst. Most of the mucosa was eroded by marked inflammation. The remaining mucosa consisted of various types of epithelium, the major type having the nature of primitive gastric mucosa. Of interest was the presence of hamartomatous components in the wall. Furthermore, the non-neoplastic mucosal lining cells around the carcinoid tumor expressed neuroendocrine antigens and had minimal proliferative activity, suggesting that part of the cyst wall provided a microenvironment for accelerated differentiation of epithelial cells to an endocrine phenotype and transformation to neoplasia.

KW - Carcinoid tumor

KW - Duodenum

KW - Duplication cyst

UR - http://www.scopus.com/inward/record.url?scp=33645772935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645772935&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2006.01957.x

DO - 10.1111/j.1440-1827.2006.01957.x

M3 - Article

VL - 56

SP - 272

EP - 278

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 5

ER -