TY - JOUR
T1 - Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation
AU - Munakata, Wataru
AU - Nomoto, Junko
AU - Takahashi, Noriko
AU - Taniguchi, Hirokazu
AU - Maeshima, Akiko Miyagi
AU - Asamura, Hisao
AU - Tanosaki, Ryuji
AU - Heike, Yuji
AU - Fukuda, Takahiro
AU - Tobinai, Kensei
AU - Kobayashi, Yukio
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Secondary cancers developing after allogeneic hematopoietic stem cell transplantation generally originate from recipient-derived cells. In this study, we analyzed the tumor cell origin of 5 epithelial malignant tumors (esophageal squamous cell carcinoma, lung adenocarcinoma, gastric adenocarcinoma, pharyngeal squamous cell carcinoma, and thyroid papillary carcinoma) that developed after allogeneic peripheral blood stem cell transplantation using anti-AE1/3 immunofluorescence with fluorescence in situ hybridization analysis for sex chromosomes and/or short-tandem repeat microsatellite analysis of laser-microdissected tumor cells. The results revealed that 1 of these 5 cancers was derived from donor cells. In this case, transfused pluripotent cells, which include both mesenchymal stem cells and hematopoietic stem cells, might have given rise to epithelial malignant cells. Our observations suggest that transfused peripheral blood cells may be involved in the development of cancers after allogeneic peripheral blood stem cell transplantation.
AB - Secondary cancers developing after allogeneic hematopoietic stem cell transplantation generally originate from recipient-derived cells. In this study, we analyzed the tumor cell origin of 5 epithelial malignant tumors (esophageal squamous cell carcinoma, lung adenocarcinoma, gastric adenocarcinoma, pharyngeal squamous cell carcinoma, and thyroid papillary carcinoma) that developed after allogeneic peripheral blood stem cell transplantation using anti-AE1/3 immunofluorescence with fluorescence in situ hybridization analysis for sex chromosomes and/or short-tandem repeat microsatellite analysis of laser-microdissected tumor cells. The results revealed that 1 of these 5 cancers was derived from donor cells. In this case, transfused pluripotent cells, which include both mesenchymal stem cells and hematopoietic stem cells, might have given rise to epithelial malignant cells. Our observations suggest that transfused peripheral blood cells may be involved in the development of cancers after allogeneic peripheral blood stem cell transplantation.
KW - FICTION
KW - STR
KW - allogeneic PBSCT
KW - donor-derived cell
KW - secondary cancer
UR - http://www.scopus.com/inward/record.url?scp=84865498120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865498120&partnerID=8YFLogxK
U2 - 10.1097/PAS.0b013e318261089c
DO - 10.1097/PAS.0b013e318261089c
M3 - Article
C2 - 22895271
AN - SCOPUS:84865498120
SN - 0147-5185
VL - 36
SP - 1376
EP - 1384
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 9
ER -
