Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation

Wataru Munakata, Junko Nomoto, Noriko Takahashi, Hirokazu Taniguchi, Akiko Miyagi Maeshima, Hisao Asamura, Ryuji Tanosaki, Yuji Heike, Takahiro Fukuda, Kensei Tobinai, Yukio Kobayashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Secondary cancers developing after allogeneic hematopoietic stem cell transplantation generally originate from recipient-derived cells. In this study, we analyzed the tumor cell origin of 5 epithelial malignant tumors (esophageal squamous cell carcinoma, lung adenocarcinoma, gastric adenocarcinoma, pharyngeal squamous cell carcinoma, and thyroid papillary carcinoma) that developed after allogeneic peripheral blood stem cell transplantation using anti-AE1/3 immunofluorescence with fluorescence in situ hybridization analysis for sex chromosomes and/or short-tandem repeat microsatellite analysis of laser-microdissected tumor cells. The results revealed that 1 of these 5 cancers was derived from donor cells. In this case, transfused pluripotent cells, which include both mesenchymal stem cells and hematopoietic stem cells, might have given rise to epithelial malignant cells. Our observations suggest that transfused peripheral blood cells may be involved in the development of cancers after allogeneic peripheral blood stem cell transplantation.

Original languageEnglish
Pages (from-to)1376-1384
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume36
Issue number9
DOIs
Publication statusPublished - 2012 Sep
Externally publishedYes

Fingerprint

Peripheral Blood Stem Cell Transplantation
Carcinoma
Neoplasms
Microsatellite Repeats
Sex Chromosomes
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Fluorescence In Situ Hybridization
Mesenchymal Stromal Cells
Fluorescent Antibody Technique
Squamous Cell Carcinoma
Blood Cells
Stomach
Adenocarcinoma
Lasers
Epithelial Cells

Keywords

  • allogeneic PBSCT
  • donor-derived cell
  • FICTION
  • secondary cancer
  • STR

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Munakata, W., Nomoto, J., Takahashi, N., Taniguchi, H., Maeshima, A. M., Asamura, H., ... Kobayashi, Y. (2012). Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation. American Journal of Surgical Pathology, 36(9), 1376-1384. https://doi.org/10.1097/PAS.0b013e318261089c

Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation. / Munakata, Wataru; Nomoto, Junko; Takahashi, Noriko; Taniguchi, Hirokazu; Maeshima, Akiko Miyagi; Asamura, Hisao; Tanosaki, Ryuji; Heike, Yuji; Fukuda, Takahiro; Tobinai, Kensei; Kobayashi, Yukio.

In: American Journal of Surgical Pathology, Vol. 36, No. 9, 09.2012, p. 1376-1384.

Research output: Contribution to journalArticle

Munakata, W, Nomoto, J, Takahashi, N, Taniguchi, H, Maeshima, AM, Asamura, H, Tanosaki, R, Heike, Y, Fukuda, T, Tobinai, K & Kobayashi, Y 2012, 'Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation', American Journal of Surgical Pathology, vol. 36, no. 9, pp. 1376-1384. https://doi.org/10.1097/PAS.0b013e318261089c
Munakata, Wataru ; Nomoto, Junko ; Takahashi, Noriko ; Taniguchi, Hirokazu ; Maeshima, Akiko Miyagi ; Asamura, Hisao ; Tanosaki, Ryuji ; Heike, Yuji ; Fukuda, Takahiro ; Tobinai, Kensei ; Kobayashi, Yukio. / Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation. In: American Journal of Surgical Pathology. 2012 ; Vol. 36, No. 9. pp. 1376-1384.
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