Cardiac cell therapy and arrhythmias

Shunichiro Miyoshi, Yukinori Ikegami, Yuji Itabashi, Akira Furuta, Akihiro Umezawa, Satoshi Ogawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cardiac stem cell based therapy is a promising therapy for patients with severe heart failure. Many types of stem cells, such as embryonic stem cells, myoblasts, marrow-derived mesenchymal stem cells, circulating endothelial progenitor cells, and cardiac precursor cells etc, are known as cellular sources for cardiac stem cell therapy. Both in the clinical and experimental setting, stem cells are reported, and supposed, to cause some arrhythmogenic adverse effects. In order to overcome these serious adverse effects, it is necessary to know the electrophysiological properties of stem cell-derived cardiomyocytes, and have a profound insight into the mechanisms of arrhythmia to know whether such arrhythmogenic properties of the cells can cause serious arrhythmia in situ. In the present study, recent publications that focus on the electrophysiological aspect of stem cell based therapy are reviewed and, furthermore, a new perspective on cardiac stem cell therapy of arrhythmias is given.

Original languageEnglish
JournalCirculation Journal
Volume71
Issue numberSUPPL. A
DOIs
Publication statusPublished - 2007

Fingerprint

Cell- and Tissue-Based Therapy
Cardiac Arrhythmias
Stem Cells
Myoblasts
Embryonic Stem Cells
Mesenchymal Stromal Cells
Cardiac Myocytes
Heart Failure
Bone Marrow

Keywords

  • Heart
  • Proarrhythmia
  • Stem cell
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Miyoshi, S., Ikegami, Y., Itabashi, Y., Furuta, A., Umezawa, A., & Ogawa, S. (2007). Cardiac cell therapy and arrhythmias. Circulation Journal, 71(SUPPL. A). https://doi.org/10.1253/circj.71.A45

Cardiac cell therapy and arrhythmias. / Miyoshi, Shunichiro; Ikegami, Yukinori; Itabashi, Yuji; Furuta, Akira; Umezawa, Akihiro; Ogawa, Satoshi.

In: Circulation Journal, Vol. 71, No. SUPPL. A, 2007.

Research output: Contribution to journalArticle

Miyoshi, S, Ikegami, Y, Itabashi, Y, Furuta, A, Umezawa, A & Ogawa, S 2007, 'Cardiac cell therapy and arrhythmias', Circulation Journal, vol. 71, no. SUPPL. A. https://doi.org/10.1253/circj.71.A45
Miyoshi S, Ikegami Y, Itabashi Y, Furuta A, Umezawa A, Ogawa S. Cardiac cell therapy and arrhythmias. Circulation Journal. 2007;71(SUPPL. A). https://doi.org/10.1253/circj.71.A45
Miyoshi, Shunichiro ; Ikegami, Yukinori ; Itabashi, Yuji ; Furuta, Akira ; Umezawa, Akihiro ; Ogawa, Satoshi. / Cardiac cell therapy and arrhythmias. In: Circulation Journal. 2007 ; Vol. 71, No. SUPPL. A.
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