TY - JOUR
T1 - Cardiac neural crest
AU - Yamagishi, Hiroyuki
N1 - Funding Information:
The author thanks Keiko Uchida, Kazuki Kodo, Chihiro Yamagishi, and Eriko Nakamura for preparation of manuscript and figures. The author’s work is supported by JSPS KAKENHI.
Publisher Copyright:
© 2021 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2021
Y1 - 2021
N2 - Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.
AB - Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.
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U2 - 10.1101/cshperspect.a036715
DO - 10.1101/cshperspect.a036715
M3 - Article
C2 - 32071091
AN - SCOPUS:85083051363
SN - 1943-0264
VL - 13
SP - 1
EP - 18
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 1
M1 - a036715
ER -
