Cardiac neural crest

Hiroyuki Yamagishi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.

Original languageEnglish
Article numbera036715
Pages (from-to)1-18
Number of pages18
JournalCold Spring Harbor Perspectives in Biology
Issue number1
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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