Cardiac repair with thymosin β4 and cardiac reprogramming factors

Deepak Srivastava, Masaki Ieda, Jidong Fu, Li Qian

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Heart disease is a leading cause of death in newborns and in adults. We previously reported that the G-actin-sequestering peptide thymosin β4 promotes myocardial survival in hypoxia and promotes neoangiogenesis, resulting in cardiac repair after injury. More recently, we showed that reprogramming of cardiac fibroblasts to cardiomyocyte-like cells in vivo after coronary artery ligation using three cardiac transcription factors (Gata4/Mef2c/Tbx5) offers an alternative approach to regenerate heart muscle. We have combined the delivery of thymosin β4 and the cardiac reprogramming factors to further enhance the degree of cardiac repair and improvement in cardiac function after myocardial infarction. These findings suggest that thymosin β4 and cardiac reprogramming technology may synergistically limit damage to the heart and promote cardiac regeneration through the stimulation of endogenous cells within the heart.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1270
Issue number1
DOIs
Publication statusPublished - 2012 Oct

Keywords

  • Cardiac repair
  • Cardiac reprogramming
  • Myocardial infarction
  • Thymosin β4

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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