Cardiovascular disease modeling using patient-specific induced pluripotent stem cells

Atsushi Tanaka, Shinsuke Yuasa, Koichi Node, Keiichi Fukuda

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders, iPSCs are an ideal platform for medical research. The pathophysiological cellular phenotypes of genetically heritable heart diseases such as arrhythmias and cardiomyopathies, have been modeled on cell culture dishes using disease-specific iPSC-derived cardiomyocytes. These model systems can potentially provide new insights into disease mechanisms and drug discoveries. This review focuses on recent progress in cardiovascular disease modeling using iPSCs, and discusses problems and future perspectives concerning their use.

Original languageEnglish
Pages (from-to)18894-18922
Number of pages29
JournalInternational journal of molecular sciences
Volume16
Issue number8
DOIs
Publication statusPublished - 2015 Aug 12

Keywords

  • Cardiovascular disease
  • Disease modeling
  • iPSCs

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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