Cardiovascular effects of intravenous and intracoronary administration of atrial natriuretic peptide in halothane anesthetized dogs

Ryoko Iwanaga, Shingo Hori, Hiromichi Suzuki, Sadao Nakajima, Takao Saruta, Shyoji Kojima, Keiichi Fukuda, Tohru Satoh, Masatoshi Kusuhara, Shunnosuke Handa, Yoshiro Nakamura, Keigo Yoshinaga, Kenn Yamaguchi

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2 Citations (Scopus)

Abstract

Cardiovascular actions of synthetic 1-28 human natriuretic peptides (hANP) were examined in dogs anesthetized with halothane. In seven closed-chest dogs a Swan-Ganz catheter was inserted for measurement of cardiac output. Intravenous infusion of increasing doses of hANP (0.1, 0.3, 0.9ug/kg/min) lowered mena aortic pressure without affecting heart rate significantly. Cardiac output and pulmonary wedge pressure were markedly decreased while total peripheral resistance was increased significantly. All these parameters returned to control levels after 1hr of recovery with an 100-150ml of saline infusion to increase pulmonary capillary wedge pressure to the pre-infusion value. Intracoronary infusion of hANP (0.05 and 0.1ug/kg/min) did not cause any significant changes in coronary flow and regional contraction. These results indicate that the hypotensive action of hANP is due to a decrease in cardiac output mediated by reduced preload but not by negative inotropic action.

Original languageEnglish
Pages (from-to)1279-1286
Number of pages8
JournalLife Sciences
Volume42
Issue number13
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Iwanaga, R., Hori, S., Suzuki, H., Nakajima, S., Saruta, T., Kojima, S., Fukuda, K., Satoh, T., Kusuhara, M., Handa, S., Nakamura, Y., Yoshinaga, K., & Yamaguchi, K. (1988). Cardiovascular effects of intravenous and intracoronary administration of atrial natriuretic peptide in halothane anesthetized dogs. Life Sciences, 42(13), 1279-1286. https://doi.org/10.1016/0024-3205(88)90221-4