Case report: Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation

S. Irie, H. Ogura, Shinichiro Okamoto, A. Tojo, K. Tani, K. Ikebuchi, N. Satoh, K. Ozawa, S. Asano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Under the assumption that in some patients with refractory anemia with excess of blasts (RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.

Original languageEnglish
Pages (from-to)316-318
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume303
Issue number5
Publication statusPublished - 1992
Externally publishedYes

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Refractory Anemia with Excess of Blasts
Granulocyte Colony-Stimulating Factor
Lymphocyte Activation
Therapeutics
Clone Cells
Leukemia

Keywords

  • Alternation therapy
  • Antileukemic agents
  • Recombinant human granulocyte colony-stimulating factor
  • Refractory anemia with excess of blasts in transformation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Case report : Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation. / Irie, S.; Ogura, H.; Okamoto, Shinichiro; Tojo, A.; Tani, K.; Ikebuchi, K.; Satoh, N.; Ozawa, K.; Asano, S.

In: American Journal of the Medical Sciences, Vol. 303, No. 5, 1992, p. 316-318.

Research output: Contribution to journalArticle

Irie, S. ; Ogura, H. ; Okamoto, Shinichiro ; Tojo, A. ; Tani, K. ; Ikebuchi, K. ; Satoh, N. ; Ozawa, K. ; Asano, S. / Case report : Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation. In: American Journal of the Medical Sciences. 1992 ; Vol. 303, No. 5. pp. 316-318.
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