Case report: Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation

S. Irie, H. Ogura, S. I. Okamoto, A. Tojo, K. Tani, K. Ikebuchi, N. Satoh, K. Ozawa, S. Asano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Under the assumption that in some patients with refractory anemia with excess of blasts (RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.

Original languageEnglish
Pages (from-to)316-318
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume303
Issue number5
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Keywords

  • Alternation therapy
  • Antileukemic agents
  • Recombinant human granulocyte colony-stimulating factor
  • Refractory anemia with excess of blasts in transformation

ASJC Scopus subject areas

  • Medicine(all)

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