Caspase in renal development

Matsuhiko Hayashi, Takashi Araki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Apoptosis is an important process for organogenesis and tissue remodelling in various normal and pathological conditions. In the apoptotic pathway, caspases play central roles, and have been studied extensively in the past decade, while their roles in renal development and organogenesis have not been elucidated yet. To reveal the roles of caspases in renal development, we have examined their activities and apoptosis in micro-dissected metanephroi. In the developing kidney, apoptotic cells showed expression of caspase-3, and inhibition of either caspase-3 or caspase-9 attenuated growth of metanephroi, indicating that the mitochondrial pathway of apoptosis plays major roles in kidney development. In addition, several growth factors are known to be involved in kidney organogenesis, such as hepatocyte growth factor. We currently are examining the roles of these growth factors and their signal transduction system; their roles in kidney organogenesis should be determined in the future.

Original languageEnglish
Pages (from-to)8-10
Number of pages3
JournalNephrology Dialysis Transplantation
Volume17
Issue numberSUPPL. 9
Publication statusPublished - 2002

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Keywords

  • Apoptosis
  • Caspase
  • Organogenesis
  • Tubulogenesis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Hayashi, M., & Araki, T. (2002). Caspase in renal development. Nephrology Dialysis Transplantation, 17(SUPPL. 9), 8-10.