Catalytic asymmetric hydrophosphonylation of ketimines

Liang Yin, Youmei Bao, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Catalytic asymmetric hydrophosphonylation of aromatic and aliphatic N-thiophosphinoyl ketimines with dialkyl phosphite was efficiently promoted by as little as 0.5 mol% of catalyst loading at ambient temperature. The catalyst can be recovered for repeated use, and facile removal of the thiophosphinoyl group allowed for ready access to the phosphonic acid analogue of enantioenriched α,α-disubstituted α-amino acids.

Original languageEnglish
Pages (from-to)10338-10341
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number28
DOIs
Publication statusPublished - 2013 Jul 17
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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