Catalytic asymmetric synthesis of mixed 3,3′-bisindoles and their evaluation as Wnt signaling inhibitors

Takayoshi Arai, Yushi Yamamoto, Atsuko Awata, Kentaro Kamiya, Masami Ishibashi, Midori A. Arai

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

TOP class: The first efficient catalytic asymmetric coupling reaction of indoles with isatin-derived nitroalkenes was accomplished by using a complex consisting of a chiral imidazoline aminophenol ligand (1; see scheme) and Cu(OTf)2. Biological activity of the newly formed chiral 3,3′-bisindoles was also confirmed in a Wnt signaling inhibitory assay.

Original languageEnglish
Pages (from-to)2486-2490
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number9
DOIs
Publication statusPublished - 2013 Feb 25

Keywords

  • 1,4-addition
  • asymmetric synthesis
  • bisindole
  • homogeneous catalysis
  • wnt signal

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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