Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group

Yuya Ota, Zhao Li, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Catalytic asymmetric syntheses of syn aldols with a methyl ketone functionality were studied to confirm the generality of the methodology. In addition, catalytic asymmetric synthesis of anti aldols with a thioamide group was carefully examined, giving the desired products, albeit with moderate diastereoselectivity.

Original languageEnglish
Pages (from-to)620-624
Number of pages5
JournalSynlett
Volume30
Issue number5
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • aldol reaction
  • catalytic asymmetric reaction
  • methyl A-Ketone
  • thioamide

ASJC Scopus subject areas

  • Organic Chemistry

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