Catalytic atropo-enantioselective reduction of biaryl lactones to axially chiral biaryl compounds

Tomoko Ashizawa, Saiko Tanaka, Tohru Yamada

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

(Chemical Equation Presented) The atropo-enantioselective borohydride reduction with dynamic kinetic resolution of biaryl lactones was catalyzed by an optically active β-ketoiminatocobalt(II) complex to afford optically active biaryl compounds. Chiral HPLC analysis of the starting biaryl lactones was performed at various temperatures to determine suitable reaction conditions for dynamic kinetic resolution. Various types of axially chiral biaryl compounds were obtained with high enantioselectivity.

Original languageEnglish
Pages (from-to)2521-2524
Number of pages4
JournalOrganic Letters
Volume10
Issue number12
DOIs
Publication statusPublished - 2008 Dec 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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