Catalytic enantioselective borohydride reduction of Ortho-fluorinated benzophenones

Ai Kokura, Saiko Tanaka, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In the presence of the optically active ketoiminatocobalt(II) complexes, the enantioselective borohydride reduction of benzophenones was successfully completed. The fluorine atom on the ortho position of the benzophenone and aryl ketones proved effective for obtaining high enantioselectivities. The combined use of modified lithium borohydride afforded the corresponding benzhydrols and arylcarbinols in high yield and high enantioselectivity (88-96% ee).

Original languageEnglish
Pages (from-to)3025-3027
Number of pages3
JournalOrganic Letters
Volume8
Issue number14
DOIs
Publication statusPublished - 2006 Jul 6

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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