Catalytic enantioselective protonation of cobalt-enolate equivalents generated by 1,4-reduction with borohydride

Yuhki Ohtsuka, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In the presence of a catalytic amount of the optically active β-ketoiminato cobalt(II) complex and borohydride modified with appropriate alcohols, the 1,4-reduction of α-substituted-α,β-unsaturated carboxamides followed by in situ enantioselective protonation proceeded smoothly to afford optically active α-substituted carboxamides with good enantiomeric excess.

Original languageEnglish
Pages (from-to)967-970
Number of pages4
JournalTetrahedron Asymmetry
Volume14
Issue number8
DOIs
Publication statusPublished - 2003 Apr 18

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Borohydrides
borohydrides
Protonation
Cobalt
alcohols
Alcohols
cobalt

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Catalytic enantioselective protonation of cobalt-enolate equivalents generated by 1,4-reduction with borohydride. / Ohtsuka, Yuhki; Ikeno, Taketo; Yamada, Tohru.

In: Tetrahedron Asymmetry, Vol. 14, No. 8, 18.04.2003, p. 967-970.

Research output: Contribution to journalArticle

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