Catalytic enantioselective protonation of cobalt-enolate equivalents generated by 1,4-reduction with borohydride

Yuhki Ohtsuka, Taketo Ikeno, Tohru Yamada

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Abstract

In the presence of a catalytic amount of the optically active β-ketoiminato cobalt(II) complex and borohydride modified with appropriate alcohols, the 1,4-reduction of α-substituted-α,β-unsaturated carboxamides followed by in situ enantioselective protonation proceeded smoothly to afford optically active α-substituted carboxamides with good enantiomeric excess.

Original languageEnglish
Pages (from-to)967-970
Number of pages4
JournalTetrahedron Asymmetry
Volume14
Issue number8
DOIs
Publication statusPublished - 2003 Apr 18

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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