Catalytic Oligopeptide Synthesis

Zijian Liu, Hidetoshi Noda, Masakatsu Shibasaki, Naoya Kumagai

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Waste-free catalytic assembly of α-amino acids is fueled by a multiboron catalyst that features a characteristic B3NO2 heterocycle, providing a versatile catalytic protocol wherein functionalized natural α-amino acid units are accommodated and commonly used protecting groups are tolerated. The facile dehydrative conditions eliminate the use of engineered peptide coupling reagents, exemplifying a greener catalytic alternative for peptide coupling. The catalysis is sufficiently robust to enable pentapeptide synthesis, constructing all four amide bond linkages in a catalytic fashion.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalOrganic Letters
Volume20
Issue number3
DOIs
Publication statusPublished - 2018 Feb 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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