Catalytic silylation of secondary alcohols by pyridine N-oxide derivative

Keisuke Yoshida; Ken Ichi Takao

doi:10.1016/j.tetlet.2014.10.087

Catalytic silylation of secondary alcohols by pyridine N-oxide derivative

Keisuke Yoshida, Ken Ichi Takao

Department of Applied Chemistry

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

The reaction of t-butyldiphenylsilyl (TBDPS) chloride with secondary alcohols was catalyzed by pyrrolidinopyridine N-oxide (PPYO) in the presence of diisopropylethylamine (DIPEA) at room temperature, giving the corresponding TBDPS ethers in high yields.

Original language	English
Pages (from-to)	6861-6863
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2014.10.087
Publication status	Published - 2014 Dec 10

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Keywords

Organocatalyst
Pyridine N-oxide
Secondary alcohols
Silylation

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Yoshida, K., & Takao, K. I. (2014). Catalytic silylation of secondary alcohols by pyridine N-oxide derivative. Tetrahedron Letters, 55(50), 6861-6863. https://doi.org/10.1016/j.tetlet.2014.10.087

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abstract = "The reaction of t-butyldiphenylsilyl (TBDPS) chloride with secondary alcohols was catalyzed by pyrrolidinopyridine N-oxide (PPYO) in the presence of diisopropylethylamine (DIPEA) at room temperature, giving the corresponding TBDPS ethers in high yields.",

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AB - The reaction of t-butyldiphenylsilyl (TBDPS) chloride with secondary alcohols was catalyzed by pyrrolidinopyridine N-oxide (PPYO) in the presence of diisopropylethylamine (DIPEA) at room temperature, giving the corresponding TBDPS ethers in high yields.

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Access to Document

10.1016/j.tetlet.2014.10.087