Catheter-related blood stream infection caused by Dermacoccus barathri, representing the first case of Dermacoccus infection in humans

Nobuhiro Takahashi, Masayoshi Shinjo(H), Hirofumi Tomita, Akihiro Fujino, Kayoko Sugita, Yasuhiro Katohno, Tatsuo Kuroda, Ken Kikuchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 7-year-old boy undergoing home parenteral nutrition with totally implantable central venous access device for chronic intestinal pseudo-obstruction experienced repeated episodes of fever with a temperature above 39.0°C despite the antibiotic treatment. The fever was considered to be catheter-related blood stream infections, as no other etiology could be justified. Repeated blood culture tests revealed negative after 1-week incubation, whereas some samples of blood collected from the central venous catheter yielded positive and gram-positive rods were detected. These bacteria were detected repeatedly, then the central venous access device was removed with consideration for the possibility of this bacteria being a pathogen. Thereafter, the fever did not recur and the blood culture tests were negative. The causative agent was identified as Dermacoccus barathri based on the 16S rRNA gene sequence and phylogenetic analysis of 6118-bp concatenated sequences of 4 housekeeping genes. Genus Dermacoccus are one form of Actinomycetes isolated from human skin and water, but human infection with Dermacoccus spp. has not been previously reported and the pathogenicity of the bacteria remains unclear. To our knowledge, this is the first reported case of Dermacoccus infection in humans.

Original languageEnglish
Pages (from-to)613-616
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume21
Issue number8
DOIs
Publication statusPublished - 2015 Aug 1

Fingerprint

Fever
Catheters
Bacteria
Infection
Gram-Positive Rods
Home Parenteral Nutrition
Intestinal Pseudo-Obstruction
Equipment and Supplies
Central Venous Catheters
Actinobacteria
Essential Genes
rRNA Genes
Sequence Analysis
Virulence
Anti-Bacterial Agents
Skin
Temperature
Water
Blood Culture
Therapeutics

Keywords

  • Catheter-related blood stream infection
  • Chronic intestinal pseudo-obstruction
  • Dermacoccus barathri
  • Ethanol lock therapy
  • Sepsis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Catheter-related blood stream infection caused by Dermacoccus barathri, representing the first case of Dermacoccus infection in humans. / Takahashi, Nobuhiro; Shinjo(H), Masayoshi; Tomita, Hirofumi; Fujino, Akihiro; Sugita, Kayoko; Katohno, Yasuhiro; Kuroda, Tatsuo; Kikuchi, Ken.

In: Journal of Infection and Chemotherapy, Vol. 21, No. 8, 01.08.2015, p. 613-616.

Research output: Contribution to journalArticle

Takahashi, Nobuhiro ; Shinjo(H), Masayoshi ; Tomita, Hirofumi ; Fujino, Akihiro ; Sugita, Kayoko ; Katohno, Yasuhiro ; Kuroda, Tatsuo ; Kikuchi, Ken. / Catheter-related blood stream infection caused by Dermacoccus barathri, representing the first case of Dermacoccus infection in humans. In: Journal of Infection and Chemotherapy. 2015 ; Vol. 21, No. 8. pp. 613-616.
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