Causal relationship between indium compound inhalation and effects on the lungs

Makiko Nakano, Kazuyuki Omae, Akiyo Tanaka, Miyuki Hirata, Takehiro Michikawa, Yuriko Kikuchi, Noriyuki Yoshioka, Yuji Nishiwaki, Tatsuya Chonan

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Background: Recent case reports and epidemiological studies suggest that inhalation of indium dust induces lung damage. Objectives: To elucidate the dose-dependent effects of indium on the lungs and to prove a causal relationship more clearly. Methods: A baseline observation was conducted on 465 workers currently exposed to indium, 127 workers formerly exposed to indium and 169 workers without indium exposure in 12 factories and 1 research laboratory from 2003 to 2006. Indium in serum (In-S) was determined as an exposure parameter, and its effects on the lungs were examined. Results: The means of In-S in the current, former and no exposure workers were 8.35, 9.63 and 0.56 ng/ml, respectively. The current and former exposure workers had significantly higher levels of KL-6, and showed significant dose-dependent increases in KL-6, SP-D, and SP-A. Current exposure workers with In-S of 3 ng/ml or above demonstrated a significant increase of KL-6 in both GM and prevalence exceeding the reference value. Approximately a quarter of the former exposure workers had interstitial changes as seen on chest HRCT. In-S of exposed workers who had been working before improvements of the working environment (Group Bef) and those who started working after improvements (Group Aft) were 12.29 and 0.81 ng/ml, respectively. Adjusted odds ratios indicated 87%, 71% and 44% reductions among Group Aft workers who exceeded the reference values of KL-6, SP-D and SP-A, respectively. Conclusion: Dose-dependent lung effects due to indium exposure were shown, and a decrease of indium exposure reduced the lung effects. An In-S value of 3 ng/ml may be a cut-off value which could be used to prevent early effects on the lungs.

Original languageEnglish
Pages (from-to)513-521
Number of pages9
JournalJournal of Occupational Health
Volume51
Issue number6
DOIs
Publication statusPublished - 2009 Nov

Fingerprint

Indium compounds
Indium
Inhalation
Lung
Pulmonary Surfactant-Associated Protein D
Serum
Medicine
Reference Values
Public Health Schools
Preventive Medicine
Public health
Research laboratories

Keywords

  • Cross-sectional study
  • HRCT
  • Indium
  • Interstitial pneumonitis
  • KL-6
  • SP-D

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Nakano, M., Omae, K., Tanaka, A., Hirata, M., Michikawa, T., Kikuchi, Y., ... Chonan, T. (2009). Causal relationship between indium compound inhalation and effects on the lungs. Journal of Occupational Health, 51(6), 513-521. https://doi.org/10.1539/joh.L9077

Causal relationship between indium compound inhalation and effects on the lungs. / Nakano, Makiko; Omae, Kazuyuki; Tanaka, Akiyo; Hirata, Miyuki; Michikawa, Takehiro; Kikuchi, Yuriko; Yoshioka, Noriyuki; Nishiwaki, Yuji; Chonan, Tatsuya.

In: Journal of Occupational Health, Vol. 51, No. 6, 11.2009, p. 513-521.

Research output: Contribution to journalArticle

Nakano, M, Omae, K, Tanaka, A, Hirata, M, Michikawa, T, Kikuchi, Y, Yoshioka, N, Nishiwaki, Y & Chonan, T 2009, 'Causal relationship between indium compound inhalation and effects on the lungs', Journal of Occupational Health, vol. 51, no. 6, pp. 513-521. https://doi.org/10.1539/joh.L9077
Nakano, Makiko ; Omae, Kazuyuki ; Tanaka, Akiyo ; Hirata, Miyuki ; Michikawa, Takehiro ; Kikuchi, Yuriko ; Yoshioka, Noriyuki ; Nishiwaki, Yuji ; Chonan, Tatsuya. / Causal relationship between indium compound inhalation and effects on the lungs. In: Journal of Occupational Health. 2009 ; Vol. 51, No. 6. pp. 513-521.
@article{2e5c9e49601f4d3687dd9904c289564b,
title = "Causal relationship between indium compound inhalation and effects on the lungs",
abstract = "Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Background: Recent case reports and epidemiological studies suggest that inhalation of indium dust induces lung damage. Objectives: To elucidate the dose-dependent effects of indium on the lungs and to prove a causal relationship more clearly. Methods: A baseline observation was conducted on 465 workers currently exposed to indium, 127 workers formerly exposed to indium and 169 workers without indium exposure in 12 factories and 1 research laboratory from 2003 to 2006. Indium in serum (In-S) was determined as an exposure parameter, and its effects on the lungs were examined. Results: The means of In-S in the current, former and no exposure workers were 8.35, 9.63 and 0.56 ng/ml, respectively. The current and former exposure workers had significantly higher levels of KL-6, and showed significant dose-dependent increases in KL-6, SP-D, and SP-A. Current exposure workers with In-S of 3 ng/ml or above demonstrated a significant increase of KL-6 in both GM and prevalence exceeding the reference value. Approximately a quarter of the former exposure workers had interstitial changes as seen on chest HRCT. In-S of exposed workers who had been working before improvements of the working environment (Group Bef) and those who started working after improvements (Group Aft) were 12.29 and 0.81 ng/ml, respectively. Adjusted odds ratios indicated 87{\%}, 71{\%} and 44{\%} reductions among Group Aft workers who exceeded the reference values of KL-6, SP-D and SP-A, respectively. Conclusion: Dose-dependent lung effects due to indium exposure were shown, and a decrease of indium exposure reduced the lung effects. An In-S value of 3 ng/ml may be a cut-off value which could be used to prevent early effects on the lungs.",
keywords = "Cross-sectional study, HRCT, Indium, Interstitial pneumonitis, KL-6, SP-D",
author = "Makiko Nakano and Kazuyuki Omae and Akiyo Tanaka and Miyuki Hirata and Takehiro Michikawa and Yuriko Kikuchi and Noriyuki Yoshioka and Yuji Nishiwaki and Tatsuya Chonan",
year = "2009",
month = "11",
doi = "10.1539/joh.L9077",
language = "English",
volume = "51",
pages = "513--521",
journal = "Journal of Occupational Health",
issn = "1341-9145",
publisher = "Japan Society for Occupational Health",
number = "6",

}

TY - JOUR

T1 - Causal relationship between indium compound inhalation and effects on the lungs

AU - Nakano, Makiko

AU - Omae, Kazuyuki

AU - Tanaka, Akiyo

AU - Hirata, Miyuki

AU - Michikawa, Takehiro

AU - Kikuchi, Yuriko

AU - Yoshioka, Noriyuki

AU - Nishiwaki, Yuji

AU - Chonan, Tatsuya

PY - 2009/11

Y1 - 2009/11

N2 - Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Background: Recent case reports and epidemiological studies suggest that inhalation of indium dust induces lung damage. Objectives: To elucidate the dose-dependent effects of indium on the lungs and to prove a causal relationship more clearly. Methods: A baseline observation was conducted on 465 workers currently exposed to indium, 127 workers formerly exposed to indium and 169 workers without indium exposure in 12 factories and 1 research laboratory from 2003 to 2006. Indium in serum (In-S) was determined as an exposure parameter, and its effects on the lungs were examined. Results: The means of In-S in the current, former and no exposure workers were 8.35, 9.63 and 0.56 ng/ml, respectively. The current and former exposure workers had significantly higher levels of KL-6, and showed significant dose-dependent increases in KL-6, SP-D, and SP-A. Current exposure workers with In-S of 3 ng/ml or above demonstrated a significant increase of KL-6 in both GM and prevalence exceeding the reference value. Approximately a quarter of the former exposure workers had interstitial changes as seen on chest HRCT. In-S of exposed workers who had been working before improvements of the working environment (Group Bef) and those who started working after improvements (Group Aft) were 12.29 and 0.81 ng/ml, respectively. Adjusted odds ratios indicated 87%, 71% and 44% reductions among Group Aft workers who exceeded the reference values of KL-6, SP-D and SP-A, respectively. Conclusion: Dose-dependent lung effects due to indium exposure were shown, and a decrease of indium exposure reduced the lung effects. An In-S value of 3 ng/ml may be a cut-off value which could be used to prevent early effects on the lungs.

AB - Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Background: Recent case reports and epidemiological studies suggest that inhalation of indium dust induces lung damage. Objectives: To elucidate the dose-dependent effects of indium on the lungs and to prove a causal relationship more clearly. Methods: A baseline observation was conducted on 465 workers currently exposed to indium, 127 workers formerly exposed to indium and 169 workers without indium exposure in 12 factories and 1 research laboratory from 2003 to 2006. Indium in serum (In-S) was determined as an exposure parameter, and its effects on the lungs were examined. Results: The means of In-S in the current, former and no exposure workers were 8.35, 9.63 and 0.56 ng/ml, respectively. The current and former exposure workers had significantly higher levels of KL-6, and showed significant dose-dependent increases in KL-6, SP-D, and SP-A. Current exposure workers with In-S of 3 ng/ml or above demonstrated a significant increase of KL-6 in both GM and prevalence exceeding the reference value. Approximately a quarter of the former exposure workers had interstitial changes as seen on chest HRCT. In-S of exposed workers who had been working before improvements of the working environment (Group Bef) and those who started working after improvements (Group Aft) were 12.29 and 0.81 ng/ml, respectively. Adjusted odds ratios indicated 87%, 71% and 44% reductions among Group Aft workers who exceeded the reference values of KL-6, SP-D and SP-A, respectively. Conclusion: Dose-dependent lung effects due to indium exposure were shown, and a decrease of indium exposure reduced the lung effects. An In-S value of 3 ng/ml may be a cut-off value which could be used to prevent early effects on the lungs.

KW - Cross-sectional study

KW - HRCT

KW - Indium

KW - Interstitial pneumonitis

KW - KL-6

KW - SP-D

UR - http://www.scopus.com/inward/record.url?scp=74549114137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74549114137&partnerID=8YFLogxK

U2 - 10.1539/joh.L9077

DO - 10.1539/joh.L9077

M3 - Article

VL - 51

SP - 513

EP - 521

JO - Journal of Occupational Health

JF - Journal of Occupational Health

SN - 1341-9145

IS - 6

ER -