Cbln and C1q family proteins - New transneuronal cytokines

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.

Original languageEnglish
Pages (from-to)1698-1705
Number of pages8
JournalCellular and Molecular Life Sciences
Volume65
Issue number11
DOIs
Publication statusPublished - 2008 Jun

Fingerprint

Plasticity
Brain
Neuronal Plasticity
Cytokines
Synapses
Neurology
Proteins
Stabilization
Tumor Necrosis Factor-alpha
Purkinje Cells
Endocytosis
Central Nervous System

Keywords

  • Cerebellin
  • Cerebellum
  • Granule cell
  • Purkinje cell
  • Synapse formation
  • Synaptic plasticity
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Cbln and C1q family proteins - New transneuronal cytokines. / Yuzaki, Michisuke.

In: Cellular and Molecular Life Sciences, Vol. 65, No. 11, 06.2008, p. 1698-1705.

Research output: Contribution to journalArticle

@article{cfb938e17b0d459fbf784d8120cb17d1,
title = "Cbln and C1q family proteins - New transneuronal cytokines",
abstract = "The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.",
keywords = "Cerebellin, Cerebellum, Granule cell, Purkinje cell, Synapse formation, Synaptic plasticity, Tumor necrosis factor",
author = "Michisuke Yuzaki",
year = "2008",
month = "6",
doi = "10.1007/s00018-008-7550-3",
language = "English",
volume = "65",
pages = "1698--1705",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "11",

}

TY - JOUR

T1 - Cbln and C1q family proteins - New transneuronal cytokines

AU - Yuzaki, Michisuke

PY - 2008/6

Y1 - 2008/6

N2 - The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.

AB - The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.

KW - Cerebellin

KW - Cerebellum

KW - Granule cell

KW - Purkinje cell

KW - Synapse formation

KW - Synaptic plasticity

KW - Tumor necrosis factor

UR - http://www.scopus.com/inward/record.url?scp=44749091014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44749091014&partnerID=8YFLogxK

U2 - 10.1007/s00018-008-7550-3

DO - 10.1007/s00018-008-7550-3

M3 - Article

C2 - 18278437

AN - SCOPUS:44749091014

VL - 65

SP - 1698

EP - 1705

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 11

ER -