Abstract
The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
| Original language | English |
|---|---|
| Pages (from-to) | 1698-1705 |
| Number of pages | 8 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 65 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2008 Jun |
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Keywords
- Cerebellin
- Cerebellum
- Granule cell
- Purkinje cell
- Synapse formation
- Synaptic plasticity
- Tumor necrosis factor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
Cbln and C1q family proteins - New transneuronal cytokines. / Yuzaki, Michisuke.
In: Cellular and Molecular Life Sciences, Vol. 65, No. 11, 06.2008, p. 1698-1705.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cbln and C1q family proteins - New transneuronal cytokines
AU - Yuzaki, Michisuke
PY - 2008/6
Y1 - 2008/6
N2 - The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
AB - The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
KW - Cerebellin
KW - Cerebellum
KW - Granule cell
KW - Purkinje cell
KW - Synapse formation
KW - Synaptic plasticity
KW - Tumor necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=44749091014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44749091014&partnerID=8YFLogxK
U2 - 10.1007/s00018-008-7550-3
DO - 10.1007/s00018-008-7550-3
M3 - Article
C2 - 18278437
AN - SCOPUS:44749091014
VL - 65
SP - 1698
EP - 1705
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 11
ER -