CCND1 Amplification Predicts Sensitivity to Chemotherapy and Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma

Ryuichiro Ishiguro, Masato Fujii, Taku Yamashita, Masatsugu Tashiro, Toshiki Tomita, Kaoru Ogawa, Kaori Kameyama

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12 Citations (Scopus)

Abstract

Background: Cyclin D1 has been reported to be associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). Patients and Methods: FISH was performed on 58 patients. Thirty-two received neoadjuvant chemotherapy (NAC) as primary treatment and 21 with hypopharyngeal squamous cell carcinoma (HPC) received chemoradiotherapy. Results: CCND1 amplification was identified in 31 (53%) patients and the incidence was higher in HPC (p=0.0068). Four (31%) out of 13 patients with CCND1 amplification responded to NAC whereas the response rate in the non-amplified group was 79% (p=0.011). CCND1 amplification with a homogeneously staining region (HSR) was accompanied by cyclin D1 protein overexpression (p<0.0001). HPC showed HSR more frequently (p=0.033) and the survival rate of the subgroup with HSR was lower than that without (p<0.05). Conclusion: Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.

Original languageEnglish
Pages (from-to)5213-5220
Number of pages8
JournalAnticancer research
Volume23
Issue number6 D
Publication statusPublished - 2003 Nov 1

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Keywords

  • Chemoradiotherapy
  • Cyclin D1
  • Fluorescence in situ hybridization (FISH)
  • Head and neck squamous cell carcinoma (HNSCC)
  • Homogeneously staining region (HSR)
  • Immunohistochemistry
  • Neoadjuvant chemotherapy (NAC)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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