Abstract
Background: Cyclin D1 has been reported to be associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). Patients and Methods: FISH was performed on 58 patients. Thirty-two received neoadjuvant chemotherapy (NAC) as primary treatment and 21 with hypopharyngeal squamous cell carcinoma (HPC) received chemoradiotherapy. Results: CCND1 amplification was identified in 31 (53%) patients and the incidence was higher in HPC (p=0.0068). Four (31%) out of 13 patients with CCND1 amplification responded to NAC whereas the response rate in the non-amplified group was 79% (p=0.011). CCND1 amplification with a homogeneously staining region (HSR) was accompanied by cyclin D1 protein overexpression (p<0.0001). HPC showed HSR more frequently (p=0.033) and the survival rate of the subgroup with HSR was lower than that without (p<0.05). Conclusion: Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.
| Original language | English |
|---|---|
| Pages (from-to) | 5213-5220 |
| Number of pages | 8 |
| Journal | Anticancer research |
| Volume | 23 |
| Issue number | 6 D |
| Publication status | Published - 2003 Nov 1 |
Keywords
- Chemoradiotherapy
- Cyclin D1
- Fluorescence in situ hybridization (FISH)
- Head and neck squamous cell carcinoma (HNSCC)
- Homogeneously staining region (HSR)
- Immunohistochemistry
- Neoadjuvant chemotherapy (NAC)
ASJC Scopus subject areas
- Oncology
- Cancer Research
