CD11 molecule defines two types of suppressor cells within the T8+ population

Tsutomu Takeuchi, Marjorie DiMaggio, Herbert Levine, Stuart F. Schlossman, Chikao Morimoto

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Abstract

It has been shown that T8+ cells are comprised of functionally heterogeneous subpopulations such as suppressor, cytotoxic, and NK cells. In this report, we attempted to delineate the functional heterogeneity of T8 cells defined by anti-CD11 antibody (anti-Mol). Although allospecific cytotoxic activity was restricted to the T8+Mol- subset, suppression of PWM IgG synthesis could be elicited in both the T8+Mol+ and the T8+Mol- subset of cells. However, the mechanism of suppression was different in these two subsets. Suppression by the T8+Mol- subset of cells required the interaction with the T4+2H4+ suppressor inducer cells, whereas the T8+Mol+ subset of cells could suppress in the absence of the suppressor inducer cells. Moreover, recombinant interleukin-2 alone could augment this suppression by the T8+Mol+ subset, but did not induce suppression by the T8+Mol- subset. In contrast, NK and LAK activity was exclusively found in the T8+Mol+ subset of cells but not in the T8+Mol- subset of cells. These results suggest that the CD11 molecule is useful for distinguishing novel subsets of T8 cells.

Original languageEnglish
Pages (from-to)398-409
Number of pages12
JournalCellular Immunology
Volume111
Issue number2
DOIs
Publication statusPublished - 1988 Feb
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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