CD30 and the NPM-ALK fusion protein (p80) are differentially expressed between peripheral blood and bone marrow in primary small cell variant of anaplastic large cell lymphoma

Norihiro Awaya, Shigehisa Mori, Hitoshi Takeuchi, Shigeo Mori, Yasuo Sugano, Tamihiro Kamata, Tsutomu Takeuchi, Toru Abe

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM-ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cell variant is prone to have a leukemic presentation. Although the small cell variant has been recognized as a subtype of ALCL, the clinical properties of this subtype, especially the immunophenotype of lymphoma cells in peripheral blood, have not yet been fully described. This report shows that neither CD30 nor p80 is detected by immunostaining in the predominant small cell malignant clone and also in large lymphoma cells in peripheral blood, while large cells and occasionally observed small cells in bone marrow were found to be positive for CD30 and p80. Our findings suggest that differential expression of CD30 and p80 between peripheral blood and bone marrow lymphoma cells is a property of the small cell variant of ALCL.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalAmerican journal of hematology
Volume69
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Anaplastic large cell lymphoma
  • NPM-ALK fusion protein
  • Peripheral blood
  • Small cell variant

ASJC Scopus subject areas

  • Hematology

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