CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Toshiyuki Morii, Yoichi Ohno, Norihiro Kato, Hiroshi Hirose, Hiroshi Kawabe, Keiichi Hirao, Takashi Eguchi, Tatsuya Maruyama, Matsuhiko Hayashi, Ikuo Saito, Yoshio Yazaki, Takao Saruta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalBiomarkers
Volume14
Issue number4
DOIs
Publication statusPublished - 2009 Jun

Fingerprint

Polymorphism
LDL Cholesterol
Single Nucleotide Polymorphism
Nucleotides
Genes
Plasmas
Scavenger Receptors
Foam Cells
Macrophages
3' Untranslated Regions
Foams
Alleles
Genotype
Population

Keywords

  • CD36
  • LDL-cholesterol
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. / Morii, Toshiyuki; Ohno, Yoichi; Kato, Norihiro; Hirose, Hiroshi; Kawabe, Hiroshi; Hirao, Keiichi; Eguchi, Takashi; Maruyama, Tatsuya; Hayashi, Matsuhiko; Saito, Ikuo; Yazaki, Yoshio; Saruta, Takao.

In: Biomarkers, Vol. 14, No. 4, 06.2009, p. 207-212.

Research output: Contribution to journalArticle

Morii, T, Ohno, Y, Kato, N, Hirose, H, Kawabe, H, Hirao, K, Eguchi, T, Maruyama, T, Hayashi, M, Saito, I, Yazaki, Y & Saruta, T 2009, 'CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men', Biomarkers, vol. 14, no. 4, pp. 207-212. https://doi.org/10.1080/13547500902811274
Morii, Toshiyuki ; Ohno, Yoichi ; Kato, Norihiro ; Hirose, Hiroshi ; Kawabe, Hiroshi ; Hirao, Keiichi ; Eguchi, Takashi ; Maruyama, Tatsuya ; Hayashi, Matsuhiko ; Saito, Ikuo ; Yazaki, Yoshio ; Saruta, Takao. / CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. In: Biomarkers. 2009 ; Vol. 14, No. 4. pp. 207-212.
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