CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Toshiyuki Morii; Yoichi Ohno; Norihiro Kato; Hiroshi Hirose; Hiroshi Kawabe; Keiichi Hirao; Takashi Eguchi; Tatsuya Maruyama; Matsuhiko Hayashi; Ikuo Saito; Yoshio Yazaki; Takao Saruta

doi:10.1080/13547500902811274

CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Toshiyuki Morii, Yoichi Ohno, Norihiro Kato, Hiroshi Hirose, Hiroshi Kawabe, Keiichi Hirao, Takashi Eguchi, Tatsuya Maruyama, Matsuhiko Hayashi, Ikuo Saito, Yoshio Yazaki, Takao Saruta

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Abstract

Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl ^-1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

Original language	English
Pages (from-to)	207-212
Number of pages	6
Journal	Biomarkers
Volume	14
Issue number	4
DOIs	https://doi.org/10.1080/13547500902811274
Publication status	Published - 2009 Jun

Keywords

CD36
LDL-cholesterol
Single nucleotide polymorphism

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.1080/13547500902811274

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CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. / Morii, Toshiyuki; Ohno, Yoichi; Kato, Norihiro; Hirose, Hiroshi; Kawabe, Hiroshi; Hirao, Keiichi; Eguchi, Takashi; Maruyama, Tatsuya; Hayashi, Matsuhiko; Saito, Ikuo; Yazaki, Yoshio; Saruta, Takao.

In: Biomarkers, Vol. 14, No. 4, 06.2009, p. 207-212.

Research output: Contribution to journal › Article › peer-review

Morii, Toshiyuki ; Ohno, Yoichi ; Kato, Norihiro ; Hirose, Hiroshi ; Kawabe, Hiroshi ; Hirao, Keiichi ; Eguchi, Takashi ; Maruyama, Tatsuya ; Hayashi, Matsuhiko ; Saito, Ikuo ; Yazaki, Yoshio ; Saruta, Takao. / CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. In: Biomarkers. 2009 ; Vol. 14, No. 4. pp. 207-212.

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abstract = "Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.",

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note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (C) Medical Genome Science from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We thank all the study participants who contributed their DNA for making this study possible. We also thank Hirokazu Sakai for help with DNA analysis.",

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AU - Hirose, Hiroshi

AU - Kawabe, Hiroshi

AU - Hirao, Keiichi

AU - Eguchi, Takashi

AU - Maruyama, Tatsuya

AU - Hayashi, Matsuhiko

AU - Saito, Ikuo

AU - Yazaki, Yoshio

AU - Saruta, Takao

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (C) Medical Genome Science from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We thank all the study participants who contributed their DNA for making this study possible. We also thank Hirokazu Sakai for help with DNA analysis.

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AB - Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

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CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Abstract

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