CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Toshiyuki Morii; Yoichi Ohno; Norihiro Kato; Hiroshi Hirose; Hiroshi Kawabe; Keiichi Hirao; Takashi Eguchi; Tatsuya Maruyama; Matsuhiko Hayashi; Ikuo Saito; Yoshio Yazaki; Takao Saruta

doi:10.1080/13547500902811274

CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Toshiyuki Morii, Yoichi Ohno, Norihiro Kato, Hiroshi Hirose, Hiroshi Kawabe, Keiichi Hirao, Takashi Eguchi, Tatsuya Maruyama, Matsuhiko Hayashi, Ikuo Saito, Yoshio Yazaki, Takao Saruta

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl ^-1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

Original language	English
Pages (from-to)	207-212
Number of pages	6
Journal	Biomarkers
Volume	14
Issue number	4
DOIs	https://doi.org/10.1080/13547500902811274
Publication status	Published - 2009 Jun 1

Keywords

CD36
LDL-cholesterol
Single nucleotide polymorphism

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

Access to Document

10.1080/13547500902811274

Fingerprint Dive into the research topics of 'CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men'. Together they form a unique fingerprint.

Cite this

Morii, T., Ohno, Y., Kato, N., Hirose, H., Kawabe, H., Hirao, K., Eguchi, T., Maruyama, T., Hayashi, M., Saito, I., Yazaki, Y., & Saruta, T. (2009). CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. Biomarkers, 14(4), 207-212. https://doi.org/10.1080/13547500902811274

CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. / Morii, Toshiyuki; Ohno, Yoichi; Kato, Norihiro; Hirose, Hiroshi; Kawabe, Hiroshi; Hirao, Keiichi; Eguchi, Takashi; Maruyama, Tatsuya; Hayashi, Matsuhiko; Saito, Ikuo; Yazaki, Yoshio; Saruta, Takao.

In: Biomarkers, Vol. 14, No. 4, 01.06.2009, p. 207-212.

Research output: Contribution to journal › Article

Morii, Toshiyuki ; Ohno, Yoichi ; Kato, Norihiro ; Hirose, Hiroshi ; Kawabe, Hiroshi ; Hirao, Keiichi ; Eguchi, Takashi ; Maruyama, Tatsuya ; Hayashi, Matsuhiko ; Saito, Ikuo ; Yazaki, Yoshio ; Saruta, Takao. / CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. In: Biomarkers. 2009 ; Vol. 14, No. 4. pp. 207-212.

@article{5ad5a08e10fd41b18bfb24f4581d0765,

title = "CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men",

abstract = "Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.",

keywords = "CD36, LDL-cholesterol, Single nucleotide polymorphism",

author = "Toshiyuki Morii and Yoichi Ohno and Norihiro Kato and Hiroshi Hirose and Hiroshi Kawabe and Keiichi Hirao and Takashi Eguchi and Tatsuya Maruyama and Matsuhiko Hayashi and Ikuo Saito and Yoshio Yazaki and Takao Saruta",

year = "2009",

month = jun,

day = "1",

doi = "10.1080/13547500902811274",

language = "English",

volume = "14",

pages = "207--212",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

AU - Morii, Toshiyuki

AU - Ohno, Yoichi

AU - Kato, Norihiro

AU - Hirose, Hiroshi

AU - Kawabe, Hiroshi

AU - Hirao, Keiichi

AU - Eguchi, Takashi

AU - Maruyama, Tatsuya

AU - Hayashi, Matsuhiko

AU - Saito, Ikuo

AU - Yazaki, Yoshio

AU - Saruta, Takao

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

AB - Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

KW - CD36

KW - LDL-cholesterol

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=68549104437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68549104437&partnerID=8YFLogxK

U2 - 10.1080/13547500902811274

DO - 10.1080/13547500902811274

M3 - Article

C2 - 19489681

AN - SCOPUS:68549104437

VL - 14

SP - 207

EP - 212

JO - Biomarkers

JF - Biomarkers

SN - 1354-750X

IS - 4

ER -