Abstract
Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.
| Original language | English |
|---|---|
| Pages (from-to) | 207-212 |
| Number of pages | 6 |
| Journal | Biomarkers |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 Jun |
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Keywords
- CD36
- LDL-cholesterol
- Single nucleotide polymorphism
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men. / Morii, Toshiyuki; Ohno, Yoichi; Kato, Norihiro; Hirose, Hiroshi; Kawabe, Hiroshi; Hirao, Keiichi; Eguchi, Takashi; Maruyama, Tatsuya; Hayashi, Matsuhiko; Saito, Ikuo; Yazaki, Yoshio; Saruta, Takao.
In: Biomarkers, Vol. 14, No. 4, 06.2009, p. 207-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men
AU - Morii, Toshiyuki
AU - Ohno, Yoichi
AU - Kato, Norihiro
AU - Hirose, Hiroshi
AU - Kawabe, Hiroshi
AU - Hirao, Keiichi
AU - Eguchi, Takashi
AU - Maruyama, Tatsuya
AU - Hayashi, Matsuhiko
AU - Saito, Ikuo
AU - Yazaki, Yoshio
AU - Saruta, Takao
PY - 2009/6
Y1 - 2009/6
N2 - Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.
AB - Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.
KW - CD36
KW - LDL-cholesterol
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=68549104437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68549104437&partnerID=8YFLogxK
U2 - 10.1080/13547500902811274
DO - 10.1080/13547500902811274
M3 - Article
VL - 14
SP - 207
EP - 212
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 4
ER -