CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report

Hideaki Nakajima, Masahiro Kizaki, Yohko Kawai, Akaru Ishida, Michihide Tokuhira, Kiyoaki Watanabe, Yasuo Ikeda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and l-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalKeio Journal of Medicine
Volume45
Issue number2
DOIs
Publication statusPublished - 1996 Jun

Keywords

  • CD7
  • acute lymphoblastic leukemia
  • cytosine arabinoside
  • mitoxantrone
  • treatment

ASJC Scopus subject areas

  • Medicine(all)

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