CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report

Hideaki Nakajima; Masahiro Kizaki; Yohko Kawai; Akaru Ishida; Michihide Tokuhira; Kiyoaki Watanabe; Yasuo Ikeda

doi:10.2302/kjm.45.114

CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report

Hideaki Nakajima, Masahiro Kizaki, Yohko Kawai, Akaru Ishida, Michihide Tokuhira, Kiyoaki Watanabe, Yasuo Ikeda

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and l-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.

Original language	English
Pages (from-to)	114-117
Number of pages	4
Journal	Keio Journal of Medicine
Volume	45
Issue number	2
DOIs	https://doi.org/10.2302/kjm.45.114
Publication status	Published - 1996 Jun

Keywords

CD7
acute lymphoblastic leukemia
cytosine arabinoside
mitoxantrone
treatment

ASJC Scopus subject areas

Medicine(all)

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10.2302/kjm.45.114

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title = "CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report",

abstract = "A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and l-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.",

keywords = "CD7, acute lymphoblastic leukemia, cytosine arabinoside, mitoxantrone, treatment",

author = "Hideaki Nakajima and Masahiro Kizaki and Yohko Kawai and Akaru Ishida and Michihide Tokuhira and Kiyoaki Watanabe and Yasuo Ikeda",

year = "1996",

month = jun,

doi = "10.2302/kjm.45.114",

language = "English",

volume = "45",

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T2 - A case report

AU - Nakajima, Hideaki

AU - Kizaki, Masahiro

AU - Kawai, Yohko

AU - Ishida, Akaru

AU - Tokuhira, Michihide

AU - Watanabe, Kiyoaki

AU - Ikeda, Yasuo

PY - 1996/6

Y1 - 1996/6

N2 - A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and l-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.

AB - A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and l-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.

KW - CD7

KW - acute lymphoblastic leukemia

KW - cytosine arabinoside

KW - mitoxantrone

KW - treatment

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CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report

Abstract

Keywords

ASJC Scopus subject areas

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