Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

Sonja Rakić, Shigeaki Kanatani, David Hunt, Clare Faux, Anna Cariboni, Francesca Chiara, Shabana Khan, Olivia Wansbury, Beatrice Howard, Kazunori Nakajima, Margareta Nikolić, John G. Parnavelas

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.

Original languageEnglish
Pages (from-to)991-1003
Number of pages13
JournalCerebral Cortex
Volume25
Issue number4
DOIs
Publication statusPublished - 2015 Apr 1

Keywords

  • cerebral cortex
  • interneurons
  • migration
  • mouse
  • phosphorylation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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  • Cite this

    Rakić, S., Kanatani, S., Hunt, D., Faux, C., Cariboni, A., Chiara, F., Khan, S., Wansbury, O., Howard, B., Nakajima, K., Nikolić, M., & Parnavelas, J. G. (2015). Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons. Cerebral Cortex, 25(4), 991-1003. https://doi.org/10.1093/cercor/bht290