Cell adhesion system and human cancer morphogenesis

Setsuo Hirohashi, Yae Kanai

Research output: Contribution to journalReview article

Abstract

Cell-cell adhesion determines the polarity of cells and participates in the maintenance of the cell societies called tissues. Cell-cell adhesiveness is generally reduced in human cancers. Reduced intercellular adhesiveness allows cancer cells to disobey the social order, resulting in destruction of histological structure, which is the morphological hallmark of malignant tumors. Reduced intercellular adhesiveness is also indispensable for cancer invasion and metastasis. A tumor-suppressor gene product, E-cadherin, and its undercoat proteins, catenins, which connect cadherins to actin filaments, are located at lateral borders, concentrating on adherens junctions, of epithelial cells and establish firm cell-cell adhesion. The E-cadherin cell adhesion system in cancer cells is inactivated by various mechanisms that reflect the morphological and biological characteristics of the tumor. Silencing of the E-cadherin gene by DNA hypermethylation around the promoter region occurs frequently, even in precancerous conditions. In diffuse infiltrating cancers, mutations are found in the genes for E-cadherin and α- and β-catenins. At the invading front of cancers, the E-cadherin cell adhesion system is inactivated by tyrosine phosphorylation of β-catenin; an oncogene product, c-erbB-2 protein, is found to associate directly with β-catenin. The E-cadherin cell adhesion system cross-talks with the Wingless/Wnt signaling pathway through β-catenin, and expression of genes, which participate in cancer morphogenesis, may be regulated in conjunction with the Wingless/Wnt signaling pathway. Dysadherin, a newly identified cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes cancer metastasis. In conclusion, inactivation of the E-cadherin cell adhesion system by both genetic and epigenetic mechanisms plays a significant role during multistage human carcinogenesis.

Original languageEnglish
Pages (from-to)13-26
Number of pages14
JournalGann Monographs on Cancer Research
Volume52
Publication statusPublished - 2004 Jul
Externally publishedYes

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Morphogenesis
Cell Adhesion
Cadherins
Catenins
Neoplasms
Adhesiveness
Wnt Signaling Pathway
Precancerous Conditions
ErbB-2 Receptor
Neoplasm Metastasis
Adherens Junctions
Cell Polarity
Oncogene Proteins
Membrane Glycoproteins
Tumor Suppressor Genes
Actin Cytoskeleton
Genetic Promoter Regions
Epigenomics
Genes
Tyrosine

ASJC Scopus subject areas

  • Cancer Research

Cite this

Cell adhesion system and human cancer morphogenesis. / Hirohashi, Setsuo; Kanai, Yae.

In: Gann Monographs on Cancer Research, Vol. 52, 07.2004, p. 13-26.

Research output: Contribution to journalReview article

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