Cell cycle as operational unit of neocortical neuronogenesis

Takao Takahashi, R. S. Nowakowski, V. S. Caviness

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Neuronogenesis in the ventricular epithelium is the initial process in a succession of histogenetic events that give rise to the laminate neocortex. Herein, we review experimental findings in mouse that support the thesis that cell cycle is the operational unit of the neuronogenetic sequence. We show that the principal regulated parameters of proliferation progress uniformly as functions of cycle number and are independent of location in the proliferative epithelium. These parameters are the duration of the G1 phase of the cell cycle and Q, the fraction of cells that leaves the cycle after mitosis. Furthermore, the specification of neuronal class and possibly also specification of a regional protomap occur coordinately with cell cycle across the expanse of the proliferative epithelium. This coordinate progression of histogenetic events with cell cycles invites the hypothesis that the mechanisms of cell cycle regulation are interdependent in proliferative cells.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalNeuroscientist
Volume5
Issue number3
DOIs
Publication statusPublished - 1999 May

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Cell Cycle
Epithelium
Neocortex
G1 Phase
Mitosis

Keywords

  • Cell cycle
  • Mouse neocortex
  • Neocortical histogenesis
  • Neocortical neuronogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cell cycle as operational unit of neocortical neuronogenesis. / Takahashi, Takao; Nowakowski, R. S.; Caviness, V. S.

In: Neuroscientist, Vol. 5, No. 3, 05.1999, p. 155-163.

Research output: Contribution to journalArticle

Takahashi, Takao ; Nowakowski, R. S. ; Caviness, V. S. / Cell cycle as operational unit of neocortical neuronogenesis. In: Neuroscientist. 1999 ; Vol. 5, No. 3. pp. 155-163.
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