Cell delivery: From cell transplantation to organ engineering

Alejandro Soto-Gutierrez, Hiroshi Yagi, Basak E. Uygun, Nalu Navarro-Alvarez, Korkut Uygun, Naoya Kobayashi, Yong Guang Yang, Martin L. Yarmush

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Cell populations derived from adult tissue and stem cells possess a great expectation for the treatment of several diseases. Great efforts have been made to generate cells with therapeutic impact from stem cells. However, it is clear that the development of systems to deliver such cells to induce efficient engraftment, growth, and function is a real necessity. Biologic and artificial scaffolds have received significant attention for their potential therapeutic application when use to form tissues in vitro and facilitate engraftment in vivo. Ultimately more sophisticated methods for decellularization of organs have been successfully used in tissue engineering and regenerative medicine applications. These decellularized tissues and organs appear to provide bioactive molecules and bioinductive properties to induce homing, differentiation, and proliferation of cells. The combination of decellularized organs and stem cells may dramatically improve the survival, engraftment, and fate control of transplanted stem cells and their ultimate clinical utility, opening the doors to a new era of organ engineering.

Original languageEnglish
Pages (from-to)655-665
Number of pages11
JournalCell Transplantation
Volume19
Issue number6-7
DOIs
Publication statusPublished - 2010

Keywords

  • Cell transplant
  • Decellularized matrices
  • Natural scaffolds
  • Organ engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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