TY - GEN
T1 - Cell-encapsulating chitosan-collagen hybrid hydrogel conduit for peripheral nerve regeneration
AU - Itai, Shun
AU - Suzuki, Karin
AU - Kurashina, Yuta
AU - Kimura, Hiroo
AU - Amemiya, Tsuyoshi
AU - Sato, Kazuki
AU - Nakamura, Masaya
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was partly supported by Translational Research program; Strategic PRomotion for practical application of INnovative medical Technology (TR-SPRINT), Japan Agency for Medical Research and Development(AMED), Japan.
Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - This paper presents a tube-shaped chitosan-collagen hydrogel conduit containing cells for peripheral nerve regeneration. The conduit is simply made by molding, and composed of two layers: A chitosan layer strengthens the conduit mechanically, and a collagen layer provides a scaffold for cells supporting the axonal extension. By using our conduit, peripheral nerves could be regenerated in high quality, because those encapsulated cells release paracrine factors including nerve growth factors (NGF) and supply good environments for nerve tissue reconstruction. We examined the biocompatibility and bioabsorbability of our conduit, and the results represent that our device induced the extension of neurites of neural model cells and was dissolved away in specific terms. We believe this conduit will become a cutting-edge conduit for peripheral nerve surgeries.
AB - This paper presents a tube-shaped chitosan-collagen hydrogel conduit containing cells for peripheral nerve regeneration. The conduit is simply made by molding, and composed of two layers: A chitosan layer strengthens the conduit mechanically, and a collagen layer provides a scaffold for cells supporting the axonal extension. By using our conduit, peripheral nerves could be regenerated in high quality, because those encapsulated cells release paracrine factors including nerve growth factors (NGF) and supply good environments for nerve tissue reconstruction. We examined the biocompatibility and bioabsorbability of our conduit, and the results represent that our device induced the extension of neurites of neural model cells and was dissolved away in specific terms. We believe this conduit will become a cutting-edge conduit for peripheral nerve surgeries.
KW - Cell culture
KW - Chitosan
KW - Collagen
KW - Peripheral nerve
KW - Regenerative medicine
KW - Tube
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M3 - Conference contribution
AN - SCOPUS:85094953871
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 880
EP - 881
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -