Cell-encapsulating chitosan-collagen hybrid hydrogel conduit for peripheral nerve regeneration

Shun Itai, Karin Suzuki, Yuta Kurashina, Hiroo Kimura, Tsuyoshi Amemiya, Kazuki Sato, Masaya Nakamura, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a tube-shaped chitosan-collagen hydrogel conduit containing cells for peripheral nerve regeneration. The conduit is simply made by molding, and composed of two layers: A chitosan layer strengthens the conduit mechanically, and a collagen layer provides a scaffold for cells supporting the axonal extension. By using our conduit, peripheral nerves could be regenerated in high quality, because those encapsulated cells release paracrine factors including nerve growth factors (NGF) and supply good environments for nerve tissue reconstruction. We examined the biocompatibility and bioabsorbability of our conduit, and the results represent that our device induced the extension of neurites of neural model cells and was dissolved away in specific terms. We believe this conduit will become a cutting-edge conduit for peripheral nerve surgeries.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages880-881
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 2019 Oct 272019 Oct 31

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period19/10/2719/10/31

Keywords

  • Cell culture
  • Chitosan
  • Collagen
  • Peripheral nerve
  • Regenerative medicine
  • Tube

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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