Cell fibers: Construction of centimeter-scale 3D tissues by weaving

Hiroaki Onoe, Riho Gojo, Yukiko Tsuda, Daisuke Kiriya, Midori Kato-Negishi, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

This paper describes "cell fibers" for engineering centimeter-scale 3D heterogeneous artificial tissues. Cells (both cell lines and primary cells) proliferate in our collagen/alginate core-shell hydrogel fibers, and completely fill the core space to form cell fibers. We found that the cell fibers keep their fibrous shapes even after removing the shell alginate hydrogel, and that they still maintain their bioactivities. As a demonstration, we constructed (i) tissue fabric sheets by weaving the cell fibers and (ii) 3D heterogeneous coil-like tissue tubes by reeling up two different cell fibers. These cell fibers would be an extremely effective tool as building elements for constructing large-scale functional tissues.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages629-631
Number of pages3
Volume1
Publication statusPublished - 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Fingerprint

Tissue
Fibers
Alginate
Hydrogels
Bioactivity
Collagen
Demonstrations
Cells

Keywords

  • 3D structure
  • Cell encapsulation
  • Hydrogel fiber
  • Tissue engineering
  • Woven structure

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Onoe, H., Gojo, R., Tsuda, Y., Kiriya, D., Kato-Negishi, M., & Takeuchi, S. (2010). Cell fibers: Construction of centimeter-scale 3D tissues by weaving. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 1, pp. 629-631)

Cell fibers : Construction of centimeter-scale 3D tissues by weaving. / Onoe, Hiroaki; Gojo, Riho; Tsuda, Yukiko; Kiriya, Daisuke; Kato-Negishi, Midori; Takeuchi, Shoji.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1 2010. p. 629-631.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Onoe, H, Gojo, R, Tsuda, Y, Kiriya, D, Kato-Negishi, M & Takeuchi, S 2010, Cell fibers: Construction of centimeter-scale 3D tissues by weaving. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. vol. 1, pp. 629-631, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 10/10/3.
Onoe H, Gojo R, Tsuda Y, Kiriya D, Kato-Negishi M, Takeuchi S. Cell fibers: Construction of centimeter-scale 3D tissues by weaving. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1. 2010. p. 629-631
Onoe, Hiroaki ; Gojo, Riho ; Tsuda, Yukiko ; Kiriya, Daisuke ; Kato-Negishi, Midori ; Takeuchi, Shoji. / Cell fibers : Construction of centimeter-scale 3D tissues by weaving. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1 2010. pp. 629-631
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