Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity

Ryotaro Iwasaki, Ken Ninomiya, Kana Miyamoto, Toru Suzuki, Yuiko Sato, Hiromasa Kawana, Taneaki Nakagawa, Toshio Suda, Takeshi Miyamoto

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The balance between osteoclast and osteoblast activity is central for maintaining the integrity of bone homeostasis. Here we show that mice lacking dendritic cell specific transmembrane protein (DC-STAMP), an essential molecule for osteoclast cell-cell fusion, exhibited impaired bone resorption and upregulation of bone formation by osteoblasts, which do not express DC-STAMP, which led to increased bone mass. On the contrary, DC-STAMP over-expressing transgenic (DC-STAMP-Tg) mice under the control of an actin promoter showed significantly accelerated cell-cell fusion of osteoclasts and bone resorption, with decreased osteoblastic activity and bone mass. Bone resorption and formation are known to be regulated in a coupled manner, whereas DC-STAMP regulates bone homeostasis in an un-coupled manner. Thus our results indicate that inhibition of a single molecule provides both decreased osteoclast activity and increased bone formation by osteoblasts, thereby increasing bone mass in an un-coupled and a tissue specific manner.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume377
Issue number3
DOIs
Publication statusPublished - 2008 Dec 19

Keywords

  • Bone homeostasis
  • Cell-cell fusion
  • DC-STAMP
  • Osteoclast
  • Transgenic
  • Uncoupling

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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