Cell membrane dynamics and the induction of apoptosis by lipid compounds

Keiji Fujimoto, Chizu Iwasaki, Haruma Kawaguchi, Etsuko Yasugi, Mieko Oshima

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Abstract

To investigate the induction of apoptosis by some lipid compounds which are a potent inducer of apoptosis, the plasma membrane fluidity of U937 cells was measured using the fluorescent probe, pyrene. The increase of the membrane fluidity was observed immediately after the treatment of cells with lipid inducers. We also found that the trigger of apoptosis was pulled within 30 min after treatment. Data from the dynamic light scattering experiment indicated that lipid inducers were dissolved to form the emulsion. At the very early stage of apoptosis, possibly, the well-controlled transfer of lipid inducers from the emulsion to the lipid layer of cells can bring about the increase of membrane dynamics which might lead to the induction of apoptosis. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalFEBS Letters
Volume446
Issue number1
DOIs
Publication statusPublished - 1999 Mar 5

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Keywords

  • Apoptosis
  • Apoptosis inducer
  • Emulsion
  • Isoprenoid
  • Lipid compound
  • Membrane fluidity

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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