Cell polarity and initiation of migration

Kanehiro Hayashi, K. Sekine, H. Tabata, K. Nakajima

Research output: Chapter in Book/Report/Conference proceedingChapter


One of the features of neurons in the developing central nervous system is that they migrate away from their birthplaces to their final destinations. Neurons are generated in the ventricular zone or the subventricular zone, migrate radially through the intermediate zone to reach the cortical plate, and finish their migration beneath the marginal zone. In this chapter, we introduce the historical debates concerning neuronal migration, the current models of morphological changes during the initial phase of radial neuronal migration. We also present the molecular mechanisms that underlie the initiation and the polarity regulation of migration in the developing cerebral cortex clarified by the analyses of human diseases and the advancement of molecular biology techniques.

Original languageEnglish
Title of host publicationCellular Migration and Formation of Axons and Dendrites
Subtitle of host publicationComprehensive Developmental Neuroscience
Number of pages16
ISBN (Electronic)9780128144077
ISBN (Print)9780128144084
Publication statusPublished - 2020 Jan 1


  • Basal progenitor
  • Cell polarity
  • Cytoskeletal rearrangement
  • In utero electroporation
  • Initiation of migration
  • Locomotion
  • Morphological changes
  • Multipolar cell
  • Multipolar migration
  • Pin-like morphology
  • Radial glial cell
  • Rapidly exiting population (REP)
  • Slowly exiting population (SEP)
  • Somal translocation

ASJC Scopus subject areas

  • Neuroscience(all)


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