Cell sheet approach for tissue engineering and regenerative medicine

Katsuhisa Matsuura, Rie Utoh, Kenichi Nagase, Teruo Okano

Research output: Contribution to journalReview article

131 Citations (Scopus)

Abstract

After the biotech medicine era, regenerative medicine is expected to be an advanced medicine that is capable of curing patients with difficult-to-treat diseases and physically impaired function. Our original scaffold-free cell sheet-based tissue engineering technology enables transplanted cells to be engrafted for a long time, while fully maintaining their viability. This technology has already been applied to various diseases in the clinical setting, including the cornea, esophagus, heart, periodontal ligament, and cartilage using autologous cells. Transplanted cell sheets not only replace the injured tissue and compensate for impaired function, but also deliver growth factors and cytokines in a spatiotemporal manner over a prolonged period, which leads to promotion of tissue repair. Moreover, the integration of stem cell biology and cell sheet technology with sufficient vascularization opens possibilities for fabrication of human three-dimensional vascularized dense and intact tissue grafts for regenerative medicine to parenchymal organs.

Original languageEnglish
Pages (from-to)228-239
Number of pages12
JournalJournal of Controlled Release
Volume190
DOIs
Publication statusPublished - 2014 Sep 28
Externally publishedYes

Keywords

  • Cell sheet
  • Regenerative medicine

ASJC Scopus subject areas

  • Pharmaceutical Science

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