Cell Therapy and Tissue Engineering from and toward the Uterus

Irene Cervelló, Xavier Santamaría, Kaoru Miyazaki, Tetsuo Maruyama, Carlos Simón

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Regenerative medicine offers the potential for replacement or repair of different types of cells within damaged tissues or the tissues themselves, typically through cell therapy or tissue engineering. Stem cells are critical to these approaches; indeed, the involvement of bone marrow in the differentiation of stem cells to nonhematopoietic cells is well demonstrated. Further, the contribution of bone marrow-derived stem cells in promoting neoangiogenesis has been demonstrated not only in animal models, but also in human clinical trials with an excellent safety profile. Recent evidence indicates that the endometrium is a tissue with the potential for regeneration through such approaches. The presence of donor cells in the endometrium of women receiving bone marrow transplantation suggests a hematopoietic source with the ability to renew this tissue. Here we describe the role of cell therapy with bone marrow-derived stem cells in treating endometrial dysfunction in Asherman syndrome and/or endometrial atrophy in human and murine models. Additionally, the emerging field of tissue engineering has recently been applied in the reproductive tissues-beyond the endometrium-with elegant studies involving humans and animal models.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalSeminars in Reproductive Medicine
Volume33
Issue number5
DOIs
Publication statusPublished - 2015 Aug 18

Fingerprint

Cell Engineering
Tissue Engineering
Cell- and Tissue-Based Therapy
Uterus
Stem Cells
Endometrium
Bone Marrow
Gynatresia
Animal Models
Regenerative Medicine
Bone Marrow Transplantation
Atrophy
Regeneration
Tissue Donors
Clinical Trials
Safety

Keywords

  • Asherman syndrome
  • bioengineering
  • bone marrow-derived stem cells
  • endometrium
  • somatic stem cells

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Cell Therapy and Tissue Engineering from and toward the Uterus. / Cervelló, Irene; Santamaría, Xavier; Miyazaki, Kaoru; Maruyama, Tetsuo; Simón, Carlos.

In: Seminars in Reproductive Medicine, Vol. 33, No. 5, 18.08.2015, p. 366-371.

Research output: Contribution to journalArticle

Cervelló, Irene ; Santamaría, Xavier ; Miyazaki, Kaoru ; Maruyama, Tetsuo ; Simón, Carlos. / Cell Therapy and Tissue Engineering from and toward the Uterus. In: Seminars in Reproductive Medicine. 2015 ; Vol. 33, No. 5. pp. 366-371.
@article{b837a9eef9fa4f3688cb64ce7a5fbfe9,
title = "Cell Therapy and Tissue Engineering from and toward the Uterus",
abstract = "Regenerative medicine offers the potential for replacement or repair of different types of cells within damaged tissues or the tissues themselves, typically through cell therapy or tissue engineering. Stem cells are critical to these approaches; indeed, the involvement of bone marrow in the differentiation of stem cells to nonhematopoietic cells is well demonstrated. Further, the contribution of bone marrow-derived stem cells in promoting neoangiogenesis has been demonstrated not only in animal models, but also in human clinical trials with an excellent safety profile. Recent evidence indicates that the endometrium is a tissue with the potential for regeneration through such approaches. The presence of donor cells in the endometrium of women receiving bone marrow transplantation suggests a hematopoietic source with the ability to renew this tissue. Here we describe the role of cell therapy with bone marrow-derived stem cells in treating endometrial dysfunction in Asherman syndrome and/or endometrial atrophy in human and murine models. Additionally, the emerging field of tissue engineering has recently been applied in the reproductive tissues-beyond the endometrium-with elegant studies involving humans and animal models.",
keywords = "Asherman syndrome, bioengineering, bone marrow-derived stem cells, endometrium, somatic stem cells",
author = "Irene Cervell{\'o} and Xavier Santamar{\'i}a and Kaoru Miyazaki and Tetsuo Maruyama and Carlos Sim{\'o}n",
year = "2015",
month = "8",
day = "18",
doi = "10.1055/s-0035-1559581",
language = "English",
volume = "33",
pages = "366--371",
journal = "Seminars in Reproductive Medicine",
issn = "1526-8004",
publisher = "Thieme Medical Publishers",
number = "5",

}

TY - JOUR

T1 - Cell Therapy and Tissue Engineering from and toward the Uterus

AU - Cervelló, Irene

AU - Santamaría, Xavier

AU - Miyazaki, Kaoru

AU - Maruyama, Tetsuo

AU - Simón, Carlos

PY - 2015/8/18

Y1 - 2015/8/18

N2 - Regenerative medicine offers the potential for replacement or repair of different types of cells within damaged tissues or the tissues themselves, typically through cell therapy or tissue engineering. Stem cells are critical to these approaches; indeed, the involvement of bone marrow in the differentiation of stem cells to nonhematopoietic cells is well demonstrated. Further, the contribution of bone marrow-derived stem cells in promoting neoangiogenesis has been demonstrated not only in animal models, but also in human clinical trials with an excellent safety profile. Recent evidence indicates that the endometrium is a tissue with the potential for regeneration through such approaches. The presence of donor cells in the endometrium of women receiving bone marrow transplantation suggests a hematopoietic source with the ability to renew this tissue. Here we describe the role of cell therapy with bone marrow-derived stem cells in treating endometrial dysfunction in Asherman syndrome and/or endometrial atrophy in human and murine models. Additionally, the emerging field of tissue engineering has recently been applied in the reproductive tissues-beyond the endometrium-with elegant studies involving humans and animal models.

AB - Regenerative medicine offers the potential for replacement or repair of different types of cells within damaged tissues or the tissues themselves, typically through cell therapy or tissue engineering. Stem cells are critical to these approaches; indeed, the involvement of bone marrow in the differentiation of stem cells to nonhematopoietic cells is well demonstrated. Further, the contribution of bone marrow-derived stem cells in promoting neoangiogenesis has been demonstrated not only in animal models, but also in human clinical trials with an excellent safety profile. Recent evidence indicates that the endometrium is a tissue with the potential for regeneration through such approaches. The presence of donor cells in the endometrium of women receiving bone marrow transplantation suggests a hematopoietic source with the ability to renew this tissue. Here we describe the role of cell therapy with bone marrow-derived stem cells in treating endometrial dysfunction in Asherman syndrome and/or endometrial atrophy in human and murine models. Additionally, the emerging field of tissue engineering has recently been applied in the reproductive tissues-beyond the endometrium-with elegant studies involving humans and animal models.

KW - Asherman syndrome

KW - bioengineering

KW - bone marrow-derived stem cells

KW - endometrium

KW - somatic stem cells

UR - http://www.scopus.com/inward/record.url?scp=84942549402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942549402&partnerID=8YFLogxK

U2 - 10.1055/s-0035-1559581

DO - 10.1055/s-0035-1559581

M3 - Article

VL - 33

SP - 366

EP - 371

JO - Seminars in Reproductive Medicine

JF - Seminars in Reproductive Medicine

SN - 1526-8004

IS - 5

ER -