TY - JOUR
T1 - Cell therapy for spinal cord injury using induced pluripotent stem cells
AU - Nagoshi, Narihito
AU - Tsuji, Osahiko
AU - Nakamura, Masaya
AU - Okano, Hideyuki
N1 - Funding Information:
This work was supported by the Research Center Network for the Realization of Regenerative Medicine and the Japan Agency for Medical Research and Development (AMED) ( 18bk0104050h0003 ) (to H.O.).
Publisher Copyright:
© 2019 The Japanese Society for Regenerative Medicine
PY - 2019/12
Y1 - 2019/12
N2 - For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.
AB - For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.
KW - Clinical application
KW - Induced pluripotent stem cells
KW - Neural precursor cells
KW - Spinal cord injury
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U2 - 10.1016/j.reth.2019.05.006
DO - 10.1016/j.reth.2019.05.006
M3 - Review article
AN - SCOPUS:85067085180
VL - 11
SP - 75
EP - 80
JO - Regenerative Therapy
JF - Regenerative Therapy
SN - 2352-3204
ER -