Cell therapy for spinal cord injury using induced pluripotent stem cells

Narihito Nagoshi; Osahiko Tsuji; Masaya Nakamura; Hideyuki Okano

doi:10.1016/j.reth.2019.05.006

Cell therapy for spinal cord injury using induced pluripotent stem cells

Narihito Nagoshi, Osahiko Tsuji, Masaya Nakamura, Hideyuki Okano

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.

Original language	English
Pages (from-to)	75-80
Number of pages	6
Journal	Regenerative Therapy
Volume	11
DOIs	https://doi.org/10.1016/j.reth.2019.05.006
Publication status	Published - 2019 Dec

Keywords

Clinical application
Induced pluripotent stem cells
Neural precursor cells
Spinal cord injury

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Developmental Biology

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title = "Cell therapy for spinal cord injury using induced pluripotent stem cells",

abstract = "For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.",

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author = "Narihito Nagoshi and Osahiko Tsuji and Masaya Nakamura and Hideyuki Okano",

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AU - Nagoshi, Narihito

AU - Tsuji, Osahiko

AU - Nakamura, Masaya

AU - Okano, Hideyuki

PY - 2019/12

Y1 - 2019/12

N2 - For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.

AB - For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.

KW - Clinical application

KW - Induced pluripotent stem cells

KW - Neural precursor cells

KW - Spinal cord injury

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