Cell uptake of albumin with synthetic glycolipid

Toshinori Sato, Hajime Miyaguchi, Yoshio Okahata

Research output: Contribution to journalArticle

Abstract

Internalization of albumin with synthetic glycolipid into blood cell was investigated by flow cytemeter. 1,5-Dioctyl-N-glucono-L-glutamate (2C8-glc) and dodecylmaltoside (DDM) enhanced the uptake of albumin into monocytes, but not into neutrophiles and granulocytes. Cationic lipids and anionic lipids showed no enhancment of cell uptake of albumin. Hemolysis was occured in the presence of DDM, but not in the presence of 2C8-glc. The present study suggest that synthetic glycolipid 2C8-glc is expected as a candidate for the delivery of proteins into blood monocytes.

Original languageEnglish
Pages (from-to)199-200
Number of pages2
JournalDrug Delivery System
Volume10
Issue number3
DOIs
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • albumin
  • cell uptake
  • glycolipid

ASJC Scopus subject areas

  • Pharmaceutical Science

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