Cellular and molecular basis for the regulation of inflammation by TGF-β

Akihiko Yoshimura, Yu Wakabayashi, Tomoaki Mori

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in inflammatory responses. For example, TGF-β induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-β inhibits the proliferation of immune cells as well as cytokine production via Foxp3-dependent and -independent mechanisms. Little is known about molecular mechanisms involved in immune suppression via TGF-β; however, Smad2/3 have been shown to play essential roles in Foxp3 induction as well as in IL-2 and IFN-γ suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Interaction between TGF-β and other cytokine signaling is important in establishing the balance of immunity and tolerance.

Original languageEnglish
Pages (from-to)781-792
Number of pages12
JournalJournal of Biochemistry
Volume147
Issue number6
DOIs
Publication statusPublished - 2010 Jun

Fingerprint

Transforming Growth Factors
Inflammation
Interleukin-2
Cytokines
Th17 Cells
T-cells
Interleukin-17
Regulatory T-Lymphocytes
Immunity
Interleukin-6
Cell Proliferation

Keywords

  • Immunity
  • signal transduction
  • smad
  • T cell
  • tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Cellular and molecular basis for the regulation of inflammation by TGF-β. / Yoshimura, Akihiko; Wakabayashi, Yu; Mori, Tomoaki.

In: Journal of Biochemistry, Vol. 147, No. 6, 06.2010, p. 781-792.

Research output: Contribution to journalArticle

Yoshimura, Akihiko ; Wakabayashi, Yu ; Mori, Tomoaki. / Cellular and molecular basis for the regulation of inflammation by TGF-β. In: Journal of Biochemistry. 2010 ; Vol. 147, No. 6. pp. 781-792.
@article{d9617fc6bb854a569c954884e1499566,
title = "Cellular and molecular basis for the regulation of inflammation by TGF-β",
abstract = "Transforming growth factor-β (TGF-β) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in inflammatory responses. For example, TGF-β induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-β inhibits the proliferation of immune cells as well as cytokine production via Foxp3-dependent and -independent mechanisms. Little is known about molecular mechanisms involved in immune suppression via TGF-β; however, Smad2/3 have been shown to play essential roles in Foxp3 induction as well as in IL-2 and IFN-γ suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Interaction between TGF-β and other cytokine signaling is important in establishing the balance of immunity and tolerance.",
keywords = "Immunity, signal transduction, smad, T cell, tolerance",
author = "Akihiko Yoshimura and Yu Wakabayashi and Tomoaki Mori",
year = "2010",
month = "6",
doi = "10.1093/jb/mvq043",
language = "English",
volume = "147",
pages = "781--792",
journal = "Journal of Biochemistry",
issn = "0021-924X",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Cellular and molecular basis for the regulation of inflammation by TGF-β

AU - Yoshimura, Akihiko

AU - Wakabayashi, Yu

AU - Mori, Tomoaki

PY - 2010/6

Y1 - 2010/6

N2 - Transforming growth factor-β (TGF-β) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in inflammatory responses. For example, TGF-β induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-β inhibits the proliferation of immune cells as well as cytokine production via Foxp3-dependent and -independent mechanisms. Little is known about molecular mechanisms involved in immune suppression via TGF-β; however, Smad2/3 have been shown to play essential roles in Foxp3 induction as well as in IL-2 and IFN-γ suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Interaction between TGF-β and other cytokine signaling is important in establishing the balance of immunity and tolerance.

AB - Transforming growth factor-β (TGF-β) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in inflammatory responses. For example, TGF-β induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-β inhibits the proliferation of immune cells as well as cytokine production via Foxp3-dependent and -independent mechanisms. Little is known about molecular mechanisms involved in immune suppression via TGF-β; however, Smad2/3 have been shown to play essential roles in Foxp3 induction as well as in IL-2 and IFN-γ suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Interaction between TGF-β and other cytokine signaling is important in establishing the balance of immunity and tolerance.

KW - Immunity

KW - signal transduction

KW - smad

KW - T cell

KW - tolerance

UR - http://www.scopus.com/inward/record.url?scp=77953695161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953695161&partnerID=8YFLogxK

U2 - 10.1093/jb/mvq043

DO - 10.1093/jb/mvq043

M3 - Article

VL - 147

SP - 781

EP - 792

JO - Journal of Biochemistry

JF - Journal of Biochemistry

SN - 0021-924X

IS - 6

ER -