Cellular and molecular mechanisms of neuronal migration in neocortical development

Takao Honda, Hidenori Tabata, Kazunori Nakajima

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The complicated mammalian brain structure arises from accurate movements of neurons from their birthplace to their final locations. Detailed observation of this migration process by various methods revealed that neuronal migration is highly motile and that there are different modes of migration. Moreover, mouse mutants or human disorders that disrupt normal migration have provided significant insights into molecular pathways that control the neuronal migration. Although our knowledge is still fragmentary, it is becoming clear that various molecules are participating in this process. In this review, we outline about the cellular and molecular mechanisms of neuronal migration in the cerebral cortex.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume14
Issue number3
DOIs
Publication statusPublished - 2003 Jun

Keywords

  • Locomotion
  • Neuronal migration
  • Reeler
  • Reelin
  • Somal translocation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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