Cellular dynamics of neuronal migration in the hippocampus

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A fine structure of the hippocampus is required for proper functions, and disruption of this formation by neuronal migration defects during development may play a role in some psychiatric illnesses. During hippocampal development in rodents, pyramidal neurons in the Ammon's horn are mostly generated in the ventricular zone (VZ), spent as multipolar cells just above the VZ, and then migrate radially toward the pial surface, ultimately settling into the hippocampal plate. Although this process is similar to that of neocortical projection neurons, these are not identical. In addition to numerous histological studies, the development of novel techniques gives a clear picture of the cellular dynamics of hippocampal neurons, as well as neocortical neurons. In this article, we provide an overview of the cellular mechanisms of rodent hippocampal neuronal migration including those of dentate granule cells, especially focusing on the differences of migration modes between hippocampal neurons and neocortical neurons. The unique migration mode of hippocampal pyramidal neurons might enable clonally related cells in the Ammon's horn to distribute in a horizontal fashion.

Original languageEnglish
Article number135
JournalFrontiers in Neuroscience
Volume9
Issue numberAPR
DOIs
Publication statusPublished - 2015

Fingerprint

Hippocampus
Neurons
Pyramidal Cells
Rodentia
Psychiatry

Keywords

  • Ammon's horn
  • Climbing mode
  • Dentate gyrus
  • Hippocampus
  • Layer pattern
  • Migration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cellular dynamics of neuronal migration in the hippocampus. / Hayashi, Kanehiro; Kubo, Kenichiro; Kitazawa, Ayako; Nakajima, Kazunori.

In: Frontiers in Neuroscience, Vol. 9, No. APR, 135, 2015.

Research output: Contribution to journalArticle

@article{1cfad29e65084d36b18cb39aa807bba9,
title = "Cellular dynamics of neuronal migration in the hippocampus",
abstract = "A fine structure of the hippocampus is required for proper functions, and disruption of this formation by neuronal migration defects during development may play a role in some psychiatric illnesses. During hippocampal development in rodents, pyramidal neurons in the Ammon's horn are mostly generated in the ventricular zone (VZ), spent as multipolar cells just above the VZ, and then migrate radially toward the pial surface, ultimately settling into the hippocampal plate. Although this process is similar to that of neocortical projection neurons, these are not identical. In addition to numerous histological studies, the development of novel techniques gives a clear picture of the cellular dynamics of hippocampal neurons, as well as neocortical neurons. In this article, we provide an overview of the cellular mechanisms of rodent hippocampal neuronal migration including those of dentate granule cells, especially focusing on the differences of migration modes between hippocampal neurons and neocortical neurons. The unique migration mode of hippocampal pyramidal neurons might enable clonally related cells in the Ammon's horn to distribute in a horizontal fashion.",
keywords = "Ammon's horn, Climbing mode, Dentate gyrus, Hippocampus, Layer pattern, Migration",
author = "Kanehiro Hayashi and Kenichiro Kubo and Ayako Kitazawa and Kazunori Nakajima",
year = "2015",
doi = "10.3389/fnins.2015.00135",
language = "English",
volume = "9",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "APR",

}

TY - JOUR

T1 - Cellular dynamics of neuronal migration in the hippocampus

AU - Hayashi, Kanehiro

AU - Kubo, Kenichiro

AU - Kitazawa, Ayako

AU - Nakajima, Kazunori

PY - 2015

Y1 - 2015

N2 - A fine structure of the hippocampus is required for proper functions, and disruption of this formation by neuronal migration defects during development may play a role in some psychiatric illnesses. During hippocampal development in rodents, pyramidal neurons in the Ammon's horn are mostly generated in the ventricular zone (VZ), spent as multipolar cells just above the VZ, and then migrate radially toward the pial surface, ultimately settling into the hippocampal plate. Although this process is similar to that of neocortical projection neurons, these are not identical. In addition to numerous histological studies, the development of novel techniques gives a clear picture of the cellular dynamics of hippocampal neurons, as well as neocortical neurons. In this article, we provide an overview of the cellular mechanisms of rodent hippocampal neuronal migration including those of dentate granule cells, especially focusing on the differences of migration modes between hippocampal neurons and neocortical neurons. The unique migration mode of hippocampal pyramidal neurons might enable clonally related cells in the Ammon's horn to distribute in a horizontal fashion.

AB - A fine structure of the hippocampus is required for proper functions, and disruption of this formation by neuronal migration defects during development may play a role in some psychiatric illnesses. During hippocampal development in rodents, pyramidal neurons in the Ammon's horn are mostly generated in the ventricular zone (VZ), spent as multipolar cells just above the VZ, and then migrate radially toward the pial surface, ultimately settling into the hippocampal plate. Although this process is similar to that of neocortical projection neurons, these are not identical. In addition to numerous histological studies, the development of novel techniques gives a clear picture of the cellular dynamics of hippocampal neurons, as well as neocortical neurons. In this article, we provide an overview of the cellular mechanisms of rodent hippocampal neuronal migration including those of dentate granule cells, especially focusing on the differences of migration modes between hippocampal neurons and neocortical neurons. The unique migration mode of hippocampal pyramidal neurons might enable clonally related cells in the Ammon's horn to distribute in a horizontal fashion.

KW - Ammon's horn

KW - Climbing mode

KW - Dentate gyrus

KW - Hippocampus

KW - Layer pattern

KW - Migration

UR - http://www.scopus.com/inward/record.url?scp=84928694339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928694339&partnerID=8YFLogxK

U2 - 10.3389/fnins.2015.00135

DO - 10.3389/fnins.2015.00135

M3 - Article

AN - SCOPUS:84928694339

VL - 9

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - APR

M1 - 135

ER -