Cellular variant of extraskeletal myxoid chondrosarcoma of abdominal wall - a case report with comparative immunohistochemical study on cartilaginous collagenous proteins in various myxoid mesenchymal tumors

Yoshimichi Ueda, Yasunori Okada, Isao Nakanishi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A rare cellular variant of recurrent extraskeletal myxoid chondrosarcoma occurring in the right lower abdominal wall of a 70-year-old man, is presented with emphasis on a characteristic distribution pattern of cartilaginous collagen proteins in the stroma. While the primary and the first recurrent tumors showed the typical histology of extraskeletal myxoid chondrosarcoma, the later tumor, which recurred 14 years after the first resection, comprised mostly compact nodules of proliferating anaplastic cells with little mucoid stroma. Some areas presented a hemangiopericytomatous pattern. A few nodules possessed abundant myxoid stroma. Immunohistochemically, type II collagen was demonstrated in the stroma of some cellular areas, and type VI collagen was intensely stained around individual tumor cells both in cellular and myxoid areas. In a comparative immunohistochemical study, the same distribution pattern of cartilaginous collagen proteins was observed only in skeletal myxoid chondrosarcomas, but not in other mesenchymal tumors with abundant myxoid stroma. These findings seem to support the cartilaginous nature of extraskeletal myxoid chondrosarcoma, and will facilitate the differential diagnosis of soft-tissue tumors with myxoid stroma.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of Cancer Research and Clinical Oncology
Volume118
Issue number2
DOIs
Publication statusPublished - 1992 Feb

Fingerprint

Abdominal Wall
Neoplasms
Proteins
Collagen
Collagen Type VI
Chondrosarcoma
Collagen Type II
Histology
Differential Diagnosis
Extraskeletal Myxoid Chondrosarcoma

Keywords

  • Collagen
  • Extraskeletal myxoid chondrosarcoma
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

@article{29b0209fd0534c77bffce681931b4eed,
title = "Cellular variant of extraskeletal myxoid chondrosarcoma of abdominal wall - a case report with comparative immunohistochemical study on cartilaginous collagenous proteins in various myxoid mesenchymal tumors",
abstract = "A rare cellular variant of recurrent extraskeletal myxoid chondrosarcoma occurring in the right lower abdominal wall of a 70-year-old man, is presented with emphasis on a characteristic distribution pattern of cartilaginous collagen proteins in the stroma. While the primary and the first recurrent tumors showed the typical histology of extraskeletal myxoid chondrosarcoma, the later tumor, which recurred 14 years after the first resection, comprised mostly compact nodules of proliferating anaplastic cells with little mucoid stroma. Some areas presented a hemangiopericytomatous pattern. A few nodules possessed abundant myxoid stroma. Immunohistochemically, type II collagen was demonstrated in the stroma of some cellular areas, and type VI collagen was intensely stained around individual tumor cells both in cellular and myxoid areas. In a comparative immunohistochemical study, the same distribution pattern of cartilaginous collagen proteins was observed only in skeletal myxoid chondrosarcomas, but not in other mesenchymal tumors with abundant myxoid stroma. These findings seem to support the cartilaginous nature of extraskeletal myxoid chondrosarcoma, and will facilitate the differential diagnosis of soft-tissue tumors with myxoid stroma.",
keywords = "Collagen, Extraskeletal myxoid chondrosarcoma, Immunohistochemistry",
author = "Yoshimichi Ueda and Yasunori Okada and Isao Nakanishi",
year = "1992",
month = "2",
doi = "10.1007/BF01187504",
language = "English",
volume = "118",
pages = "147--151",
journal = "Journal of Cancer Research and Clinical Oncology",
issn = "0171-5216",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Cellular variant of extraskeletal myxoid chondrosarcoma of abdominal wall - a case report with comparative immunohistochemical study on cartilaginous collagenous proteins in various myxoid mesenchymal tumors

AU - Ueda, Yoshimichi

AU - Okada, Yasunori

AU - Nakanishi, Isao

PY - 1992/2

Y1 - 1992/2

N2 - A rare cellular variant of recurrent extraskeletal myxoid chondrosarcoma occurring in the right lower abdominal wall of a 70-year-old man, is presented with emphasis on a characteristic distribution pattern of cartilaginous collagen proteins in the stroma. While the primary and the first recurrent tumors showed the typical histology of extraskeletal myxoid chondrosarcoma, the later tumor, which recurred 14 years after the first resection, comprised mostly compact nodules of proliferating anaplastic cells with little mucoid stroma. Some areas presented a hemangiopericytomatous pattern. A few nodules possessed abundant myxoid stroma. Immunohistochemically, type II collagen was demonstrated in the stroma of some cellular areas, and type VI collagen was intensely stained around individual tumor cells both in cellular and myxoid areas. In a comparative immunohistochemical study, the same distribution pattern of cartilaginous collagen proteins was observed only in skeletal myxoid chondrosarcomas, but not in other mesenchymal tumors with abundant myxoid stroma. These findings seem to support the cartilaginous nature of extraskeletal myxoid chondrosarcoma, and will facilitate the differential diagnosis of soft-tissue tumors with myxoid stroma.

AB - A rare cellular variant of recurrent extraskeletal myxoid chondrosarcoma occurring in the right lower abdominal wall of a 70-year-old man, is presented with emphasis on a characteristic distribution pattern of cartilaginous collagen proteins in the stroma. While the primary and the first recurrent tumors showed the typical histology of extraskeletal myxoid chondrosarcoma, the later tumor, which recurred 14 years after the first resection, comprised mostly compact nodules of proliferating anaplastic cells with little mucoid stroma. Some areas presented a hemangiopericytomatous pattern. A few nodules possessed abundant myxoid stroma. Immunohistochemically, type II collagen was demonstrated in the stroma of some cellular areas, and type VI collagen was intensely stained around individual tumor cells both in cellular and myxoid areas. In a comparative immunohistochemical study, the same distribution pattern of cartilaginous collagen proteins was observed only in skeletal myxoid chondrosarcomas, but not in other mesenchymal tumors with abundant myxoid stroma. These findings seem to support the cartilaginous nature of extraskeletal myxoid chondrosarcoma, and will facilitate the differential diagnosis of soft-tissue tumors with myxoid stroma.

KW - Collagen

KW - Extraskeletal myxoid chondrosarcoma

KW - Immunohistochemistry

UR - http://www.scopus.com/inward/record.url?scp=0026601097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026601097&partnerID=8YFLogxK

U2 - 10.1007/BF01187504

DO - 10.1007/BF01187504

M3 - Article

C2 - 1531226

AN - SCOPUS:0026601097

VL - 118

SP - 147

EP - 151

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

SN - 0171-5216

IS - 2

ER -