Cellulitis due to Achromobacter xylosoxidans during bortezomib therapy for multiple myeloma

Taku Kikuchi, Takehiko Mori, Sumiko Kohashi, Yusuke Yamane, Mikio Okayama, Eri Mashima, Koichi Murakami, Takayuki Shimizu, Yuichi Kurihara, Tomomi Ueda, Takeshi Suzuki, Shinichiro Okamoto

Research output: Contribution to journalArticle

Abstract

Achromobacter xylosoxidans (A. xylosoxidans) is a non-fermentative gram-negative rod. This organism is reportedly a causative pathogen of bacteremia mainly in patients with hematological disorders. However, only one case of cellulitis due to A. xylosoxidans associated with hematological malignancy has been reported. An 80-year-old man developed cellulitis and subsequent bacteremia due to A. xylosoxidans during bortezomib therapy for multiple myeloma. Although his condition was serious enough to require intensive care, he fully recovered with appropriate antimicrobial agents and supportive care. The isolate was broadly resistant to antimicrobial agents, including cefepime, amikacin, and ciprofloxacin. Therefore, the identification and selection of appropriate antimicrobial agents were considered to have contributed to the successful outcome in this case. Physicians should recognize A. xylosoxidans as a possible pathogen causing cellulitis and secondary bacteremia, as well as being aware of its broad resistance to antimicrobial agents.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume57
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Achromobacter denitrificans
Cellulitis
Anti-Infective Agents
Multiple Myeloma
Bacteremia
Amikacin
Hematologic Neoplasms
Therapeutics
Critical Care
Ciprofloxacin
Physicians
Bortezomib

ASJC Scopus subject areas

  • Medicine(all)

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Cellulitis due to Achromobacter xylosoxidans during bortezomib therapy for multiple myeloma. / Kikuchi, Taku; Mori, Takehiko; Kohashi, Sumiko; Yamane, Yusuke; Okayama, Mikio; Mashima, Eri; Murakami, Koichi; Shimizu, Takayuki; Kurihara, Yuichi; Ueda, Tomomi; Suzuki, Takeshi; Okamoto, Shinichiro.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 57, No. 2, 01.02.2016, p. 175-179.

Research output: Contribution to journalArticle

Kikuchi, Taku ; Mori, Takehiko ; Kohashi, Sumiko ; Yamane, Yusuke ; Okayama, Mikio ; Mashima, Eri ; Murakami, Koichi ; Shimizu, Takayuki ; Kurihara, Yuichi ; Ueda, Tomomi ; Suzuki, Takeshi ; Okamoto, Shinichiro. / Cellulitis due to Achromobacter xylosoxidans during bortezomib therapy for multiple myeloma. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2016 ; Vol. 57, No. 2. pp. 175-179.
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