TY - JOUR
T1 - Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats
AU - Shirakami, Gotaro
AU - Itoh, Hiroshi
AU - Suga, Shin ichi
AU - Komatsu, Yasato
AU - Hama, Norio
AU - Mori, Kenjiro
AU - Nakao, Kazuwa
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993/9/3
Y1 - 1993/9/3
N2 - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.
AB - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.
KW - Angiotensin II
KW - Arginine vasopressin
KW - Atrial natriuretic peptide
KW - C-Type natriuretic peptide
KW - Natriuretic peptide receptor
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U2 - 10.1016/0304-3940(93)90789-N
DO - 10.1016/0304-3940(93)90789-N
M3 - Article
C2 - 8264972
AN - SCOPUS:0027327894
VL - 159
SP - 25
EP - 28
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -