Abstract
The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.
| Original language | English |
|---|---|
| Pages (from-to) | 25-28 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 159 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1993 Sep 3 |
| Externally published | Yes |
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Keywords
- Angiotensin II
- Arginine vasopressin
- Atrial natriuretic peptide
- C-Type natriuretic peptide
- Natriuretic peptide receptor
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats. / Shirakami, Gotaro; Itoh, Hiroshi; Suga, Shin ichi; Komatsu, Yasato; Hama, Norio; Mori, Kenjiro; Nakao, Kazuwa.
In: Neuroscience Letters, Vol. 159, No. 1-2, 03.09.1993, p. 25-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats
AU - Shirakami, Gotaro
AU - Itoh, Hiroshi
AU - Suga, Shin ichi
AU - Komatsu, Yasato
AU - Hama, Norio
AU - Mori, Kenjiro
AU - Nakao, Kazuwa
PY - 1993/9/3
Y1 - 1993/9/3
N2 - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.
AB - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.
KW - Angiotensin II
KW - Arginine vasopressin
KW - Atrial natriuretic peptide
KW - C-Type natriuretic peptide
KW - Natriuretic peptide receptor
UR - http://www.scopus.com/inward/record.url?scp=0027327894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027327894&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90789-N
DO - 10.1016/0304-3940(93)90789-N
M3 - Article
C2 - 8264972
AN - SCOPUS:0027327894
VL - 159
SP - 25
EP - 28
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -