Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

Gotaro Shirakami; Hiroshi Itoh; Shin ichi Suga; Yasato Komatsu; Norio Hama; Kenjiro Mori; Kazuwa Nakao

doi:10.1016/0304-3940(93)90789-N

Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

Gotaro Shirakami, Hiroshi Itoh, Shin ichi Suga, Yasato Komatsu, Norio Hama, Kenjiro Mori, Kazuwa Nakao

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	159
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(93)90789-N
Publication status	Published - 1993 Sep 3
Externally published	Yes

Keywords

Angiotensin II
Arginine vasopressin
Atrial natriuretic peptide
C-Type natriuretic peptide
Natriuretic peptide receptor

ASJC Scopus subject areas

Neuroscience(all)

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title = "Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats",

abstract = "The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.",

keywords = "Angiotensin II, Arginine vasopressin, Atrial natriuretic peptide, C-Type natriuretic peptide, Natriuretic peptide receptor",

author = "Gotaro Shirakami and Hiroshi Itoh and Suga, {Shin ichi} and Yasato Komatsu and Norio Hama and Kenjiro Mori and Kazuwa Nakao",

year = "1993",

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T1 - Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

AU - Shirakami, Gotaro

AU - Itoh, Hiroshi

AU - Suga, Shin ichi

AU - Komatsu, Yasato

AU - Hama, Norio

AU - Mori, Kenjiro

AU - Nakao, Kazuwa

PY - 1993/9/3

Y1 - 1993/9/3

N2 - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

AB - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

KW - Angiotensin II

KW - Arginine vasopressin

KW - Atrial natriuretic peptide

KW - C-Type natriuretic peptide

KW - Natriuretic peptide receptor

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