Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

Gotaro Shirakami, Hiroshi Itoh, Shin ichi Suga, Yasato Komatsu, Norio Hama, Kenjiro Mori, Kazuwa Nakao

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Volume159
Issue number1-2
DOIs
Publication statusPublished - 1993 Sep 3
Externally publishedYes

Fingerprint

C-Type Natriuretic Peptide
Atrial Natriuretic Factor
Vasopressins
Atrial Natriuretic Factor Receptors
Arginine Vasopressin
Natriuretic Peptides
Injections
Angiotensin II
Central Nervous System
Ligands

Keywords

  • Angiotensin II
  • Arginine vasopressin
  • Atrial natriuretic peptide
  • C-Type natriuretic peptide
  • Natriuretic peptide receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats. / Shirakami, Gotaro; Itoh, Hiroshi; Suga, Shin ichi; Komatsu, Yasato; Hama, Norio; Mori, Kenjiro; Nakao, Kazuwa.

In: Neuroscience Letters, Vol. 159, No. 1-2, 03.09.1993, p. 25-28.

Research output: Contribution to journalArticle

Shirakami, Gotaro ; Itoh, Hiroshi ; Suga, Shin ichi ; Komatsu, Yasato ; Hama, Norio ; Mori, Kenjiro ; Nakao, Kazuwa. / Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats. In: Neuroscience Letters. 1993 ; Vol. 159, No. 1-2. pp. 25-28.
@article{9b7431edbd4a47f1838069b50a2455ee,
title = "Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats",
abstract = "The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.",
keywords = "Angiotensin II, Arginine vasopressin, Atrial natriuretic peptide, C-Type natriuretic peptide, Natriuretic peptide receptor",
author = "Gotaro Shirakami and Hiroshi Itoh and Suga, {Shin ichi} and Yasato Komatsu and Norio Hama and Kenjiro Mori and Kazuwa Nakao",
year = "1993",
month = "9",
day = "3",
doi = "10.1016/0304-3940(93)90789-N",
language = "English",
volume = "159",
pages = "25--28",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

AU - Shirakami, Gotaro

AU - Itoh, Hiroshi

AU - Suga, Shin ichi

AU - Komatsu, Yasato

AU - Hama, Norio

AU - Mori, Kenjiro

AU - Nakao, Kazuwa

PY - 1993/9/3

Y1 - 1993/9/3

N2 - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

AB - The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

KW - Angiotensin II

KW - Arginine vasopressin

KW - Atrial natriuretic peptide

KW - C-Type natriuretic peptide

KW - Natriuretic peptide receptor

UR - http://www.scopus.com/inward/record.url?scp=0027327894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027327894&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90789-N

DO - 10.1016/0304-3940(93)90789-N

M3 - Article

C2 - 8264972

AN - SCOPUS:0027327894

VL - 159

SP - 25

EP - 28

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -