Central effect of atrial natriuretic polypeptide on angiotensin II-stimulated vasopressin secretion in concious rats

Takayuki Yamada, Kazuwa Nakao, Narito Morii, Hiroshi Itoh, Shozo Shiono, Makoto Sakamoto, Akira Sugawara, Yoshihiko Saito, Hideto Ohno, Akira Kanai, Goro Katsuura, Masami Eigyo, Akira Matsushita, Hiroo Imura

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86 Citations (Scopus)

Abstract

The effect of intracerebroventricular (i.c.v.) treatment of α-human atrial natriuretic polypeptide on the vasopressin secretion induced by i.c.v. injection of angiotensin II was studied in conscious, unrestrained rats. Pretreatment of α-human atrial natriuretic polypeptide (5 μg) significantly inhibited the angiotensin II (100 ng)-stimulated vasopressin secretion. This result suggests that atrial natriuretic polypeptide plays regulatory roles in vasopressin secretion in the central nervous system.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalEuropean journal of pharmacology
Volume125
Issue number3
DOIs
Publication statusPublished - 1986 Jun 24
Externally publishedYes

Keywords

  • Angiotensin II
  • Atrial natriuretic polypeptide
  • Vasopressin

ASJC Scopus subject areas

  • Pharmacology

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    Yamada, T., Nakao, K., Morii, N., Itoh, H., Shiono, S., Sakamoto, M., Sugawara, A., Saito, Y., Ohno, H., Kanai, A., Katsuura, G., Eigyo, M., Matsushita, A., & Imura, H. (1986). Central effect of atrial natriuretic polypeptide on angiotensin II-stimulated vasopressin secretion in concious rats. European journal of pharmacology, 125(3), 453-456. https://doi.org/10.1016/0014-2999(86)90802-2