Centrally located adenocarcinoma with endobronchial polypoid growth: Clinicopathological analysis of five cases

Tomoyuki Hishida, Genichiro Ishii, Tetsuro Kodama, Koji Tsuta, Michiya Nara, Junji Yoshida, Mitsuyo Nishimura, Kanji Nagai, Atsushi Ochiai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lung adenocarcinomas that exhibit endobronchial polypoid growth and arise from the central portion of the respiratory tree are extremely rare and their clinicopathological features are not well understood. We report the clinicopathological characteristics of five cases of centrally located adenocarcinomas. Histologically, in three cases (cases 1, 2, and 3) the tumor had a papillary, acinar, and solid structure. In the other two cases (cases 4 and 5) histological examination revealed a mucin-filled glandular and cystic structure resembling mucoepidermoid carcinoma, although the lesions lacked a squamoid cell component. Immunohistochemical staining revealed that the tumor cells in all five cases were positive for MUC1 and Cytokeratin 7. The tumor cells in cases 4 and 5 were positive for MUC5AC and MUC6, and the expression pattern in these two cases was similar to that of mucoepidermoid carcinoma of the lung. Our findings allowed us to identify two distinct subtypes of centrally located adenocarcinomas with distinct morphological and immunohistochemical characteristics; these should provide new insight into the pathogenesis of central adenocarcinoma of the lung.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalPathology International
Volume61
Issue number2
DOIs
Publication statusPublished - 2011 Feb
Externally publishedYes

Fingerprint

Mucoepidermoid Carcinoma
Adenocarcinoma
Growth
Keratin-7
Neoplasms
Mucins
Cellular Structures
Staining and Labeling
Lung
Adenocarcinoma of lung

Keywords

  • Adenocarcinoma
  • Centrally located adenocarcinoma
  • Endobronchial polypoid growth
  • Lung

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Centrally located adenocarcinoma with endobronchial polypoid growth : Clinicopathological analysis of five cases. / Hishida, Tomoyuki; Ishii, Genichiro; Kodama, Tetsuro; Tsuta, Koji; Nara, Michiya; Yoshida, Junji; Nishimura, Mitsuyo; Nagai, Kanji; Ochiai, Atsushi.

In: Pathology International, Vol. 61, No. 2, 02.2011, p. 73-79.

Research output: Contribution to journalArticle

Hishida, T, Ishii, G, Kodama, T, Tsuta, K, Nara, M, Yoshida, J, Nishimura, M, Nagai, K & Ochiai, A 2011, 'Centrally located adenocarcinoma with endobronchial polypoid growth: Clinicopathological analysis of five cases', Pathology International, vol. 61, no. 2, pp. 73-79. https://doi.org/10.1111/j.1440-1827.2010.02619.x
Hishida, Tomoyuki ; Ishii, Genichiro ; Kodama, Tetsuro ; Tsuta, Koji ; Nara, Michiya ; Yoshida, Junji ; Nishimura, Mitsuyo ; Nagai, Kanji ; Ochiai, Atsushi. / Centrally located adenocarcinoma with endobronchial polypoid growth : Clinicopathological analysis of five cases. In: Pathology International. 2011 ; Vol. 61, No. 2. pp. 73-79.
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