Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells

Takayuki Nitta, Masayuki Kanai, Eiji Sugihara, Masakazu Tanaka, Binilian Sun, Toshiro Nagasawa, Shunro Sonoda, Hideyuki Saya, Masanao Miwa

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Centrosomes play pivotal roles in cell polarity, regulation of the cell cycle and chromosomal segregation. Centrosome amplification was recently described as a possible cause of aneuploidy in certain solid tumors and leukemias. ATL is a T-cell malignancy caused by HTLV-1. Although the precise mechanism of cell transformation is unclear, the HTLV-1-encoded protein, Tax, is thought to play a crucial role in leukemogenesis. Here we demonstrate that lymphocytes isolated from patients with ATL show centrosome amplification and that a human T cell line shows centrosome amplification after induction of Tax, which was suppressed by CDK inhibitors. Micronuclei formation was also observed after centrosome amplification in Tax-induced human T cells. These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV-1 and chromosomal instability in HTLV-1-infected human T cells.

Original languageEnglish
Pages (from-to)836-841
Number of pages6
JournalCancer science
Volume97
Issue number9
DOIs
Publication statusPublished - 2006 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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