Abstract
Temporomandibular disorders (TMD) represent a group of chronic painful conditions in the masticatory musculature and temporomandibular joint. To examine possible changes in cortical machinery in TMD patients, we compared neuromagnetic signals evoked by cortical neurons between healthy subjects and TMD patients while they were carefully observing the video frames of jaw-opening movements performed by another person. During the movement observation task in the healthy subjects, we found cortical activation in the following sequence with left hemisphere dominance: (1) the occipitotemporal region near the inferior temporal sulcus (human homologue of MT/V5 in monkeys), (2) the inferior parietal cortex (IPC), and (3) the anterior part of the inferior-lateral precentral gyrus (PrCG). In the TMD patients, however, we found deficit or marked attenuation of the neuromagnetic responses in the PrCG and IPC, while the activity of the MT/V5 showed no differences from that in the healthy subjects. In addition, we could not find any differences in cortical magnetic responses between healthy subjects and TMD patients when they were observing palm-opening movements, indicating that cortical dysfunction associated with jaw-movement observation is specific phenomena in the patients of TMD. Thus the present study provides new neuropathological evidence that TMD patients exhibit dysfunction of recognition mechanisms in cerebral cortex during motor observation, and suggests that disturbance of cortical functions regulating visuomotor integration would play a crucial role in development as well as aggravation of TMD.
| Original language | English |
|---|---|
| Pages (from-to) | 180-188 |
| Number of pages | 9 |
| Journal | Pain |
| Volume | 128 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2007 Mar |
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Keywords
- Human
- Magnetoencephalography
- Motor cortex
- Temporomandibular disorder
- Visual cortex
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Neurology
- Neuroscience(all)
- Pharmacology
- Clinical Psychology
Cite this
Cerebral cortical dysfunction in patients with temporomandibular disorders in association with jaw movement observation. / Shibukawa, Yoshiyuki; Ishikawa, Tatsuya; Kato, Yutaka; Zhang, Zhen Kang; Jiang, Ting; Shintani, Masuro; Shimono, Masaki; Kumai, Toshifumi; Suzuki, Takashi; Kato, Motoichiro; Nakamura, Yoshio.
In: Pain, Vol. 128, No. 1-2, 03.2007, p. 180-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral cortical dysfunction in patients with temporomandibular disorders in association with jaw movement observation
AU - Shibukawa, Yoshiyuki
AU - Ishikawa, Tatsuya
AU - Kato, Yutaka
AU - Zhang, Zhen Kang
AU - Jiang, Ting
AU - Shintani, Masuro
AU - Shimono, Masaki
AU - Kumai, Toshifumi
AU - Suzuki, Takashi
AU - Kato, Motoichiro
AU - Nakamura, Yoshio
PY - 2007/3
Y1 - 2007/3
N2 - Temporomandibular disorders (TMD) represent a group of chronic painful conditions in the masticatory musculature and temporomandibular joint. To examine possible changes in cortical machinery in TMD patients, we compared neuromagnetic signals evoked by cortical neurons between healthy subjects and TMD patients while they were carefully observing the video frames of jaw-opening movements performed by another person. During the movement observation task in the healthy subjects, we found cortical activation in the following sequence with left hemisphere dominance: (1) the occipitotemporal region near the inferior temporal sulcus (human homologue of MT/V5 in monkeys), (2) the inferior parietal cortex (IPC), and (3) the anterior part of the inferior-lateral precentral gyrus (PrCG). In the TMD patients, however, we found deficit or marked attenuation of the neuromagnetic responses in the PrCG and IPC, while the activity of the MT/V5 showed no differences from that in the healthy subjects. In addition, we could not find any differences in cortical magnetic responses between healthy subjects and TMD patients when they were observing palm-opening movements, indicating that cortical dysfunction associated with jaw-movement observation is specific phenomena in the patients of TMD. Thus the present study provides new neuropathological evidence that TMD patients exhibit dysfunction of recognition mechanisms in cerebral cortex during motor observation, and suggests that disturbance of cortical functions regulating visuomotor integration would play a crucial role in development as well as aggravation of TMD.
AB - Temporomandibular disorders (TMD) represent a group of chronic painful conditions in the masticatory musculature and temporomandibular joint. To examine possible changes in cortical machinery in TMD patients, we compared neuromagnetic signals evoked by cortical neurons between healthy subjects and TMD patients while they were carefully observing the video frames of jaw-opening movements performed by another person. During the movement observation task in the healthy subjects, we found cortical activation in the following sequence with left hemisphere dominance: (1) the occipitotemporal region near the inferior temporal sulcus (human homologue of MT/V5 in monkeys), (2) the inferior parietal cortex (IPC), and (3) the anterior part of the inferior-lateral precentral gyrus (PrCG). In the TMD patients, however, we found deficit or marked attenuation of the neuromagnetic responses in the PrCG and IPC, while the activity of the MT/V5 showed no differences from that in the healthy subjects. In addition, we could not find any differences in cortical magnetic responses between healthy subjects and TMD patients when they were observing palm-opening movements, indicating that cortical dysfunction associated with jaw-movement observation is specific phenomena in the patients of TMD. Thus the present study provides new neuropathological evidence that TMD patients exhibit dysfunction of recognition mechanisms in cerebral cortex during motor observation, and suggests that disturbance of cortical functions regulating visuomotor integration would play a crucial role in development as well as aggravation of TMD.
KW - Human
KW - Magnetoencephalography
KW - Motor cortex
KW - Temporomandibular disorder
KW - Visual cortex
UR - http://www.scopus.com/inward/record.url?scp=33846810098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846810098&partnerID=8YFLogxK
U2 - 10.1016/j.pain.2006.10.006
DO - 10.1016/j.pain.2006.10.006
M3 - Article
C2 - 17156922
AN - SCOPUS:33846810098
VL - 128
SP - 180
EP - 188
JO - Pain
JF - Pain
SN - 0304-3959
IS - 1-2
ER -