Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy

Takato Abe; Shigeru Nogawa; Norio Tanahashi; Junichi Shiraishi; Eiji Ikeda; Norihiro Suzuki

doi:10.2169/internalmedicine.46.1859

Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy

Takato Abe, Shigeru Nogawa, Norio Tanahashi, Junichi Shiraishi, Eiji Ikeda, Norihiro Suzuki

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A 34-year-old woman with hyperthyroidism, who had been previously treated with propylthiouracil (PTU) is reported. She was admitted because of clumsiness in her left hand and abnormal behavior. A neurological examination demonstrated impairment of higher cortical function, and weakness and hyperreflexia of the left leg. An MRI scan with gadolinium enhancement showed pachyleptomeningeal thickening in the right fronto-parietal lobe. Blood tests revealed a high MPO-ANCA titer of 122 EU (normal:<10 EU). After steroid administration, the neurological symptoms and the MRI findings improved markedly. This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer.

Original language	English
Pages (from-to)	247-250
Number of pages	4
Journal	Internal Medicine
Volume	46
Issue number	5
DOIs	https://doi.org/10.2169/internalmedicine.46.1859
Publication status	Published - 2007 Mar 1

Keywords

MPO-ANCA
PTU
Pachyleptomeningitis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.46.1859

Cite this

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abstract = "A 34-year-old woman with hyperthyroidism, who had been previously treated with propylthiouracil (PTU) is reported. She was admitted because of clumsiness in her left hand and abnormal behavior. A neurological examination demonstrated impairment of higher cortical function, and weakness and hyperreflexia of the left leg. An MRI scan with gadolinium enhancement showed pachyleptomeningeal thickening in the right fronto-parietal lobe. Blood tests revealed a high MPO-ANCA titer of 122 EU (normal:<10 EU). After steroid administration, the neurological symptoms and the MRI findings improved markedly. This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer.",

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AU - Abe, Takato

AU - Nogawa, Shigeru

AU - Tanahashi, Norio

AU - Shiraishi, Junichi

AU - Ikeda, Eiji

AU - Suzuki, Norihiro

PY - 2007/3/1

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AB - A 34-year-old woman with hyperthyroidism, who had been previously treated with propylthiouracil (PTU) is reported. She was admitted because of clumsiness in her left hand and abnormal behavior. A neurological examination demonstrated impairment of higher cortical function, and weakness and hyperreflexia of the left leg. An MRI scan with gadolinium enhancement showed pachyleptomeningeal thickening in the right fronto-parietal lobe. Blood tests revealed a high MPO-ANCA titer of 122 EU (normal:<10 EU). After steroid administration, the neurological symptoms and the MRI findings improved markedly. This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer.

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Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy

Abstract

Keywords

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