Cerebrovascular NADPH diaphorase-containing nerve fibers in the rat

Norihiro Suzuki, Yasuo Fukuuchi, Atsuo Koto, Yuichiro Naganuma, Kazuo Isozumi, Shizuko Matsuoka, Jun Gotoh, Toshihiko Shimizu

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


Recently, neuronal nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase has been elucidated to be the nitric oxide synthase (NOS) per se. In order to examine the existence and distribution of cerebrovascular nerve fibers containing these substances, NADPH-diaphorase histochemistry was applied to the cerebral blood vessels and the cranial ganglia known to innervate the cerebral vessels in the rat. Numerous nerve fibers with varicosities forming plexuses were observed in the circle of Willis and its branches. In addition, thick nerve bundles were seen to run along the wall of the internal ethmoidal artery. NADPH-diaphorase reaction was prominent in neurons of the sphenopalatine, otic and internal carotid ganglia. This study demonstrated, for the first time, the NADPH-diaphorase-containing nerve fibers in the cerebral vessels and ganglion cells in the parasympathetic and sensory ganglia known to innervate the cerebral vessels.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 1993 Mar 5


  • Cerebral vessel
  • NADPH-diaphorase
  • Nitric oxide
  • Nitric oxide synthase
  • Parasympathetic nerve
  • Sensory nerve

ASJC Scopus subject areas

  • Neuroscience(all)


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